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Iwai S

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Publications:

Title Authors Year Journal
Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Iwai S Nature
A cyclobutane thymine-N4-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis. Iwai S 2013 Nucleic acids research
Photosensitized [2 + 2] cycloaddition of N-acetylated cytosine affords stereoselective formation of cyclobutane pyrimidine dimer. Iwai S 2011 Nucleic acids research
Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana. Iwai S 2010 Journal of nucleic acids
Molecular analyses of an unusual translesion DNA polymerase from Methanosarcina acetivorans C2A. Iwai S 2010 Journal of molecular biology
Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions. Iwai S 2010 PLoS genetics
Human replicative DNA polymerase δ can bypass T-T (6-4) ultraviolet photoproducts on template strands. Iwai S 2010 Genes to cells : devoted to molecular & cellular mechanisms
Polymerization by DNA polymerase eta is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) cross-link: implications for cytotoxic effects in nucleotide excision repair-negative tumor cells. Iwai S 2010 Carcinogenesis
Biochemical properties and base excision repair complex formation of apurinic/apyrimidinic endonuclease from Pyrococcus furiosus. Iwai S 2009 Nucleic acids research
Biochemical evolution of DNA polymerase eta: properties of plant, human, and yeast proteins. Iwai S 2008 Biochemistry
Translesion synthesis across the (6-4) photoproduct and its Dewar valence isomer by the Y-family and engineered DNA polymerases. Iwai S 2008 Nucleic acids symposium series (2004)
REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo. Iwai S 2008 Nucleic acids research
The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair. Iwai S 2007 DNA repair
Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair. Iwai S 2006 Molecular cell
DNA polymerase iota-dependent translesion replication of uracil containing cyclobutane pyrimidine dimers. Iwai S 2006 DNA repair
Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. Iwai S 2006 The Journal of biological chemistry
Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution. Iwai S 2004 Nat Biotechnol
Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer. Iwai S 2004 Nucleic acids research
High-efficiency bypass of DNA damage by human DNA polymerase Q. Iwai S 2004 The EMBO journal
DNA binding properties of human DNA polymerase eta: implications for fidelity and polymerase switching of translesion synthesis. Iwai S 2004 Genes Cells
Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity. Iwai S 2004 Nature
Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Iwai S 2004 Molecular and cellular biology
Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha. Iwai S 2003 The Journal of biological chemistry
The Gly-952 residue of Saccharomyces cerevisiae DNA polymerase alpha is important in discriminating correct deoxyribonucleotides from incorrect ones. Iwai S 2003 The Journal of biological chemistry
Identification and characterization of an intermediate in the alkali degradation of (6-4) photoproduct-containing DNA. Iwai S 2003 The Journal of biological chemistry
Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota. Iwai S 2003 DNA repair
Translesion synthesis by human DNA polymerase eta across thymine glycol lesions. Iwai S 2002 Biochemistry
A role for DNA polymerase beta in mutagenic UV lesion bypass. Iwai S 2002 The Journal of biological chemistry
Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta. Iwai S 2001 Nucleic acids research
Mutagenic and nonmutagenic bypass of DNA lesions by Drosophila DNA polymerases dpoleta and dpoliota. Iwai S 2001 The Journal of biological chemistry
DNA polymerase iota and related rad30-like enzymes. Iwai S 2001 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Xeroderma pigmentosum variant: from a human genetic disorder to a novel DNA polymerase. Iwai S 2000 Cold Spring Harbor symposia on quantitative biology
Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota. Iwai S 2000 The EMBO journal
Mechanisms of accurate translesion synthesis by human DNA polymerase eta. Iwai S 2000 The EMBO journal
Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa. Iwai S 2000 Genes Dev
Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta. Iwai S 2000 Nucleic acids research
Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. Iwai S 1999 The EMBO journal
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Iwai S 1999 Nature
Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation. Iwai S 1993 Nucleic acids research
Cloning a defined region of DNA using a limited action of DNA polymerase: application to dissection of hepatitis B virus surface antigen gene. Iwai S 1986 Gene

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