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Götte M

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Publications:

Title Authors Year Journal
Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. Götte M 2011 The Journal of biological chemistry
Effects of mutations F61A and A62V in the fingers subdomain of HIV-1 reverse transcriptase on the translocational equilibrium. Götte M 2011 Journal of molecular biology
Mechanism of resistance to GS-9148 conferred by the Q151L mutation in HIV-1 reverse transcriptase. Götte M 2011 Antimicrobial agents and chemotherapy
Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition. Götte M 2011 The Journal of biological chemistry
Initiation of HIV reverse transcription: is enzyme flipping required? Götte M 2011 Viruses
HIV-1 reverse transcriptase connection domain mutations: dynamics of emergence and implications for success of combination antiretroviral therapy. Götte M 2010 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation. Götte M 2010 The Journal of biological chemistry
Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions. Götte M 2010 Biochimica et biophysica acta
Epidemiological and biological evidence for a compensatory effect of connection domain mutation N348I on M184V in HIV-1 reverse transcriptase. Götte M 2010 The Journal of infectious diseases
HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors. Götte M 2010 Viruses
Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme. Götte M 2009 The Journal of biological chemistry
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase. Götte M 2009 The Journal of biological chemistry
Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity. Götte M 2009 J Immunol
Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression. Götte M 2009 Carcinogenesis
Effect of testosterone on E1S-sulfatase activity in non-malignant and cancerous breast cells in vitro. Götte M 2009 J Steroid Biochem Mol Biol
Stroke work or systolic dP/dtmax to evaluate acute response to cardiac resynchronization therapy: are they interchangeable? Götte M 2009 Eur J Heart Fail
Nucleic acid polymerases use a general acid for nucleotidyl transfer. Götte M 2009 Nature structural & molecular biology
HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition. Götte M 2009 Journal of molecular biology
Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. Götte M 2008 ACS Chem Biol
Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors". Götte M 2008 The Journal of biological chemistry
Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms. Götte M 2008 The Journal of biological chemistry
Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma. Götte M 2008 J Pathol
Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Götte M 2008 Cell Host Microbe
Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids. Götte M 2008 Nucleic acids research
Effects of mutations in the connection and RNase H domains of HIV-1 reverse transcriptase on drug susceptibility. Götte M 2008 AIDS Rev
Microbial subversion of heparan sulfate proteoglycans. Götte M 2008 Mol Cells
Changes in heparan sulfate are associated with delayed wound repair, altered cell migration, adhesion and contractility in the galactosyltransferase I (beta4GalT-7) deficient form of Ehlers-Danlos syndrome. Götte M 2008 Hum Mol Genet
Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase. Götte M 2008 The Journal of biological chemistry
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Götte M 2007 Proceedings of the National Academy of Sciences of the United States of America
The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation. Götte M 2007 The Journal of biological chemistry
Insertions in the beta3-beta4 loop of reverse transcriptase of human immunodeficiency virus type 1 and their mechanism of action, influence on drug susceptibility and viral replication capacity. Götte M 2007 Antiviral Res
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir. Götte M 2007 Antimicrob Agents Chemother
Mechanisms of resistance associated with excision of incorporated nucleotide analogue inhibitors of HIV-1 reverse transcriptase. Götte M 2007 Current opinion in HIV and AIDS
Should we include connection domain mutations of HIV-1 reverse transcriptase in HIV resistance testing. Götte M 2007 PLoS medicine
Effects of nucleotides and nucleotide analogue inhibitors of HIV-1 reverse transcriptase in a ratchet model of polymerase translocation. Götte M 2006 Curr Pharm Des
Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action. Götte M 2006 J Virol
Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet. Götte M 2006 J Virol
Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in human immunodeficiency virus type 1 reverse transcriptase. Götte M 2005 Antimicrob Agents Chemother
The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations. Götte M 2005 Antimicrob Agents Chemother
Inhibition of HIV-1 reverse transcription: basic principles of drug action and resistance. Götte M 2004 Expert Rev Anti Infect Ther
Excision of incorporated nucleotide analogue chain-terminators can diminish their inhibitory effects on viral RNA-dependent RNA polymerases. Götte M 2004 Journal of molecular biology
Impact of the translocational equilibrium of HIV-1 reverse transcriptase on the efficiency of mismatch extensions and the excision of mispaired nucleotides. Götte M 2004 Int J Biochem Cell Biol
Mutations E44D and V118I in the reverse transcriptase of HIV-1 play distinct mechanistic roles in dual resistance to AZT and 3TC. Götte M 2003 The Journal of biological chemistry
Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase. Götte M 2003 Antimicrobial agents and chemotherapy
Diminished RNA primer usage associated with the L74V and M184V mutations in the reverse transcriptase of human immunodeficiency virus type 1 provides a possible mechanism for diminished viral replication capacity. Götte M 2003 Journal of virology
Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance. Götte M 2003 The Journal of biological chemistry
Negative effect of the M184V mutation in HIV-1 reverse transcriptase on initiation of viral DNA synthesis. Götte M 2003 Virology
The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase delays the development of resistance to amprenavir and efavirenz in subtype B and C clinical isolates. Götte M 2003 Antimicrobial agents and chemotherapy
Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1. Götte M 2002 Antimicrobial agents and chemotherapy
Nonradioactive detection of retroviral-associated RNase H activity in a microplate-based, high-throughput format. Götte M 2002 BioTechniques
The M184V mutation in HIV-1 reverse transcriptase reduces the restoration of wild-type replication by attenuated viruses. Götte M 2002 AIDS (London, England)
Analysis of efficiency and fidelity of HIV-1 (+)-strand DNA synthesis reveals a novel rate-limiting step during retroviral reverse transcription. Götte M 2001 The Journal of biological chemistry
Role for human immunodeficiency virus type 1 Tat protein in suppression of viral reverse transcriptase activity during late stages of viral replication. Götte M 2001 Journal of virology
The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis. Götte M 2000 J Virol
Human immunodeficiency virus type-1 reverse transcription can be inhibited in vitro by oligonucleotides that target both natural and synthetic tRNA primers. Götte M 2000 Nucleic acids research
Biochemical mechanisms involved in overcoming HIV resistance to nucleoside inhibitors of reverse transcriptase. Götte M 2000 Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
Temporal coordination between initiation of HIV (+)-strand DNA synthesis and primer removal. Götte M 1999 The Journal of biological chemistry
NMR structure of the chimeric hybrid duplex r(gcaguggc).r(gcca)d(CTGC) comprising the tRNA-DNA junction formed during initiation of HIV-1 reverse transcription. Götte M 1999 Journal of biomolecular NMR
HIV-1 reverse transcription: a brief overview focused on structure-function relationships among molecules involved in initiation of the reaction. Götte M 1999 Archives of biochemistry and biophysics
Localization of the active site of HIV-1 reverse transcriptase-associated RNase H domain on a DNA template using site-specific generated hydroxyl radicals. Götte M 1998 The Journal of biological chemistry
Mechanistic studies of early pausing events during initiation of HIV-1 reverse transcription. Götte M 1998 The Journal of biological chemistry
Dominance of the E89G substitution in HIV-1 reverse transcriptase in regard to increased polymerase processivity and patterns of pausing. Götte M 1998 The Journal of biological chemistry
Probing the higher order structure of RNA with peroxonitrous acid. Götte M 1996 FEBS letters
HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA. Götte M 1995 The EMBO journal
The 'helix clamp' in HIV-1 reverse transcriptase: a new nucleic acid binding motif common in nucleic acid polymerases. Götte M 1994 Nucleic acids research

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