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Sarafianos SG

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Publications:

Title Authors Year Journal
Restriction fragment mass polymorphism (RFMP) analysis based on MALDI-TOF mass spectrometry for detecting antiretroviral resistance in HIV-1 infected patients. Sarafianos SG 2013 Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
The Effect of Mutations at Position E138 in HIV-1 Reverse Transcriptase and their Interactions with the M184I Mutation in Defining Patterns of Resistance to the Non-Nucleoside Reverse Transcriptase Inhibitors Rilpivirine and Etravirine. Sarafianos SG 2013 Antimicrobial agents and chemotherapy
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA. Sarafianos SG 2013 Retrovirology
Effects of 4' - and 2-Substitutions on the Bioactivity of 4' -Ethynyl-2-Fluoro-2' -Deoxyadenosine. Sarafianos SG 2013 Antimicrobial agents and chemotherapy
The hepatitis B virus ribonuclease h is sensitive to inhibitors of the human immunodeficiency virus ribonuclease h and integrase enzymes. Sarafianos SG 2013 PLoS pathogens
Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity. Sarafianos SG 2012 Biology
Effect of translocation defective reverse transcriptase inhibitors on the activity of n348i, a connection subdomain drug resistant hiv-1 reverse transcriptase mutant. Sarafianos SG 2012 Cellular and molecular biology (Noisy-le-Grand, France)
Biochemical Mechanism of HIV-1 Resistance to Rilpivirine. Sarafianos SG 2012 The Journal of biological chemistry
HIV-1 reverse transcriptase (RT) polymorphism 172K, suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and nonnucleoside RT inhibitors. Sarafianos SG 2012 The Journal of biological chemistry
Antiviral therapies: Focus on hepatitis B reverse transcriptase. Sarafianos SG 2012 The international journal of biochemistry & cell biology
SARS-CoV Replication Inhibitor that Interferes with the Nucleic acid Unwinding of the Viral Helicase. Sarafianos SG 2012 Antimicrobial agents and chemotherapy
Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase. Sarafianos SG 2012 Antimicrobial agents and chemotherapy
Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates. Sarafianos SG 2011 Nucleic acids research
The Mechanism of Interaction of Human Mitochondrial DNA Polymerase γ with the Novel Nucleoside Reverse Transcriptase Inhibitor 4' -Ethynyl-2-Fluoro-2' -Deoxyadenosine Indicates a Low Potential for Host Toxicity. Sarafianos SG 2011 Antimicrobial agents and chemotherapy
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase. Sarafianos SG 2011 Nucleic acids research
The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase. Sarafianos SG 2011 Cellular and molecular biology (Noisy-le-Grand, France)
K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism. Sarafianos SG 2011 PloS one
Hepatitis B Virus genotypic differences map structurally close to NRTI resistance hot spots. Sarafianos SG 2011 International journal of current chemistry
Structural basis of HIV-1 resistance to AZT by excision. Sarafianos SG 2010 Nature structural & molecular biology
The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine. Sarafianos SG 2010 The Journal of biological chemistry
The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site. Sarafianos SG 2010 Retrovirology
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. Sarafianos SG 2009 The Journal of biological chemistry
Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patients. Sarafianos SG 2009 Antiviral research
SC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide. Sarafianos SG 2009 Antimicrobial agents and chemotherapy
Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20. Sarafianos SG 2009 The Journal of biological chemistry
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. Sarafianos SG 2009 Journal of molecular biology
2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants. Sarafianos SG 2008 The international journal of biochemistry & cell biology
Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors. Sarafianos SG 2008 J Virol
Synthesis of AZTpSpCX2ppSA and AZTpSpCX2ppSAZT: hydrolysis-resistant potential inhibitors of the AZT excision reaction of HIV-1 RT. Sarafianos SG 2007 Organic letters
3'-Azido-3'-deoxythymidine-(5')-tetraphospho-(5')-adenosine, the product of ATP-mediated excision of chain-terminating AZTMP, is a potent chain-terminating substrate for HIV-1 reverse transcriptase. Sarafianos SG 2007 Biochemistry
Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. Sarafianos SG 2007 Journal of molecular biology
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Sarafianos SG 2006 ACS Chem Biol
Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance? Sarafianos SG 2006 PLoS Pathog
Structural determinants of slippage-mediated mutations by human immunodeficiency virus type 1 reverse transcriptase. Sarafianos SG 2006 The Journal of biological chemistry
Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization. Sarafianos SG 2006 Virology
Identification of amino acid residues in the human immunodeficiency virus type-1 reverse transcriptase tryptophan-repeat motif that are required for subunit interaction using infectious virions. Sarafianos SG 2005 Journal of molecular biology
Subunit-specific analysis of the human immunodeficiency virus type 1 reverse transcriptase in vivo. Sarafianos SG 2004 J Virol
Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage. Sarafianos SG 2004 J Virol
Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases. Sarafianos SG 2004 Current opinion in structural biology
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Sarafianos SG 2004 Nature structural & molecular biology
Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision. Sarafianos SG 2004 J Virol
Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs. Sarafianos SG 2004 Int J Biochem Cell Biol
Mutations in the 5' end of the human immunodeficiency virus type 1 polypurine tract affect RNase H cleavage specificity and virus titer. Sarafianos SG 2003 J Virol
Mutation of amino acids in the connection domain of human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer affects RNase H activity. Sarafianos SG 2003 J Virol
Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design. Sarafianos SG 2003 Nucleic acids research
Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo. Sarafianos SG 2002 Proceedings of the National Academy of Sciences of the United States of America
The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1. Sarafianos SG 2002 J Virol
Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision. Sarafianos SG 2002 J Virol
Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA. Sarafianos SG 2002 The EMBO journal
RNase H cleavage of the 5' end of the human immunodeficiency virus type 1 genome. Sarafianos SG 2001 J Virol
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. Sarafianos SG 2001 The EMBO journal
Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC). Sarafianos SG 2001 J Virol
Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase. Sarafianos SG 2001 Proceedings of the National Academy of Sciences of the United States of America
YADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro. Sarafianos SG 2001 J Virol
Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase. Sarafianos SG 2001 J Virol
Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase. Sarafianos SG 2000 Biochemistry
Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase. Sarafianos SG 2000 Proceedings of the National Academy of Sciences of the United States of America
The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase. Sarafianos SG 2000 Journal of molecular biology
Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and Moloney murine leukemia virus reverse transcriptase. Sarafianos SG 1999 Journal of molecular biology
Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site. Sarafianos SG 1999 Chemistry & biology
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids. Sarafianos SG 1999 Proceedings of the National Academy of Sciences of the United States of America
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution. Sarafianos SG 1998 Journal of molecular biology
Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis. Sarafianos SG 1996 Biochemistry
Mechanism of polyoxometalate-mediated inactivation of DNA polymerases: an analysis with HIV-1 reverse transcriptase indicates specificity for the DNA-binding cleft. Sarafianos SG 1996 Biochem J
Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase. Sarafianos SG 1996 Biochemistry
Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase. Sarafianos SG 1995 Biochemistry
Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity. Sarafianos SG 1995 The Journal of biological chemistry

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