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Spadari S

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Publications:

Title Authors Year Journal
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells. Spadari S Anticancer research
Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy. Spadari S Nucleosides & nucleotides
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. Spadari S 2008 Biochemical pharmacology
Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda. Spadari S 2007 Nucleic acids research
Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants. Spadari S 2007 ChemMedChem
Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate. Spadari S 2007 Angewandte Chemie (International ed. in English)
Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. Spadari S 2006 Nucleic acids research
Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. Spadari S 2005 Nucleic acids research
DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. Spadari S 2005 The Journal of biological chemistry
Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. Spadari S 2005 Molecular pharmacology
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. Spadari S 2005 Journal of medicinal chemistry
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz. Spadari S 2005 Antimicrobial agents and chemotherapy
Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. Spadari S 2004 Biochemistry
Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication. Spadari S 2004 Antimicrobial agents and chemotherapy
HIV-1 reverse transcriptase inhibitors: current issues and future perspectives. Spadari S 2004 Current drug metabolism
Vif is an auxiliary factor of the HIV-1 reverse transcriptase and facilitates abasic site bypass. Spadari S 2004 The Biochemical journal
Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex. Spadari S 2004 Antimicrobial agents and chemotherapy
The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. Spadari S 2004 FASEB J
Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. Spadari S 2003 Biochemistry
Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity. Spadari S 2003 The Journal of biological chemistry
Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners. Spadari S 2003 The Journal of biological chemistry
Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. Spadari S 2003 Nucleic acids research
Combinations against combinations: associations of anti-HIV 1 reverse transcriptase drugs challenged by constellations of drug resistance mutations. Spadari S 2002 Current drug metabolism
Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. Spadari S 2002 The Journal of biological chemistry
Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. Spadari S 2002 The EMBO journal
DNA polymerase theta purified from human cells is a high-fidelity enzyme. Spadari S 2002 Journal of molecular biology
Eukaryotic DNA polymerases. Spadari S 2002 Annual review of biochemistry
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. Spadari S 2001 Journal of medicinal chemistry
The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors. Spadari S 2001 The Journal of biological chemistry
Replication protein A as a "fidelity clamp" for DNA polymerase alpha. Spadari S 2001 The Journal of biological chemistry
Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. Spadari S 2001 Proceedings of the National Academy of Sciences of the United States of America
Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs. Spadari S 2001 Antimicrobial agents and chemotherapy
Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes. Spadari S 2000 The Biochemical journal
Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents. Spadari S 2000 Antiviral chemistry & chemotherapy
Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes. Spadari S 2000 Antimicrobial agents and chemotherapy
DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. Spadari S 2000 Journal of molecular biology
Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs. Spadari S 1999 Nucleic acids research
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity. Spadari S 1999 Journal of medicinal chemistry
Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis. Spadari S 1999 Journal of molecular biology
Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides. Spadari S 1998 Expert opinion on investigational drugs
Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions. Spadari S 1997 Journal of molecular biology
Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate. Spadari S 1995 Nucleic acids research
Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides. Spadari S 1995 Biochimie
Aphidicolin inhibits in vitro the activity of pseudorabies virus (PRV) DNA polymerase and in vivo the viral proliferation. Spadari S 1994 In Vivo
Developmental activity profile of DNA polymerases delta and alpha in rat neurons suggests a coordinated in vivo function. Spadari S 1992 In vivo (Athens, Greece)
HP 0.35, a cephalosporin degradation product is a specific inhibitor of lentiviral RNAses H. Spadari S 1991 Nucleic acids research
Specific inhibition of human DNA ligase adenylation by a distamycin derivative possessing antitumor activity. Spadari S 1991 Nucleic acids research
Revised nomenclature for eukaryotic DNA polymerases. Spadari S 1990 Eur J Biochem
Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease. Spadari S 1990 FEBS letters
Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development. Spadari S 1990 Mutation research
Calf thymus DNA polymerase delta independent of proliferating cell nuclear antigen (PCNA). Spadari S 1989 Nucleic acids research
Do DNA polymerases delta and alpha act coordinately as leading and lagging strand replicases? Spadari S 1988 FEBS letters
Calf thymus DNA polymerase delta: purification, biochemical and functional properties of the enzyme after its separation from DNA polymerase alpha, a DNA dependent ATPase and proliferating cell nuclear antigen. Spadari S 1988 Nucleic acids research
Replication of single-stranded porcine circovirus DNA by DNA polymerases alpha and delta. Spadari S 1988 Biochimica et biophysica acta
Mammalian DNA polymerase alpha: a replication-competent holoenzyme form from calf thymus. Spadari S 1987 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Betalactam antibiotics interfere with eukaryotic DNA-replication by inhibiting DNA polymerase alpha. Spadari S 1987 Nucleic acids research
Differential incorporation of thymidylate analogues into DNA by DNA polymerase alpha and by DNA polymerases specified by two herpes simplex viruses. Spadari S 1982 The Journal of general virology
Aphidicolin does not inhibit DNA repair synthesis in ultraviolet-irradiated HeLa cells. A radioautographic study. Spadari S 1981 The Biochemical journal
An autoradiographic demonstration of nuclear DNA replication by DNA polymerase alpha and of mitochondrial DNA synthesis by DNA polymerase gamma. Spadari S 1981 Nucleic acids research
Functional roles of the plant alpha-like and gamma-like DNA polymerases. Spadari S 1981 FEBS letters
A gamma-like DNA polymerase in spinach chloroplasts. Spadari S 1980 European journal of biochemistry / FEBS
Mechanism of inhibition of herpes simplex virus and vaccinia virus DNA polymerases by aphidicolin, a highly specific inhibitor of DNA replication in eucaryotes. Spadari S 1980 Journal of virology
DNA polymerase gamma, cytochrome c oxidase and mitochondrial integrity in rabbit spleen lymphocytes stimulated with concanavalin A. Spadari S 1980 Exp Cell Res
Synchronization of HeLa cell cultures by inhibition of DNA polymerase alpha with aphidicolin. Spadari S 1980 Nucleic acids research
Specific and reversible inhibition by aphidicolin in the alpha-like DNA polymerase of plant cells. Spadari S 1980 FEBS letters
Functions of DNA polymerases alpha, beta, and gamma in neurons during development. Spadari S 1979 Cold Spring Harbor symposia on quantitative biology
DNA polymerase beta from brain neurons is a repair enzyme. Spadari S 1979 European journal of biochemistry / FEBS
Effect of aphidicolin on viral and human DNA polymerases. Spadari S 1979 Biochemical and biophysical research communications
Enhancement of the rate of DNA polymerase-alpha activity on duplex DNA by a DNA-binding protein and a DNA-dependent ATPase of mammalian cells. Spadari S 1979 Cold Spring Harbor symposia on quantitative biology
Functional roles of DNA polymerases beta and gamma. Spadari S 1979 Proceedings of the National Academy of Sciences of the United States of America
DNA polymerase alpha, beta and gamma activities in rabbit spleen cell populations stimulated by various doses of concanavalin A. Spadari S 1978 Exp Cell Res
Variation of DNA polymerases-alpha, -beta. and -gamma during perinatal tissue growth and differentiation. Spadari S 1977 Nucleic acids research
Identity of DNA polymerase gamma from synaptosomal mitochondria and rat-brain nuclei. Spadari S 1977 European journal of biochemistry / FEBS
Variations of DNA polymerase-alpha and -beta during prolonged stimulation of human lymphocytes. Spadari S 1976 Proceedings of the National Academy of Sciences of the United States of America
RNA-primed DNA synthesis: specific catalysis by HeLa cell DNA polymerase alpha. Spadari S 1975 Proceedings of the National Academy of Sciences of the United States of America
The dissimilitude of the low and high molecular weight deoxyribonucleic acid-dependent deoxyribonucleic acid polymerases of HeLa cells. Spadari S 1974 The Journal of biological chemistry
HeLa cell R-deoxyribonucleic acid polymerases. Separation and characterization of two enzymatic activities. Spadari S 1974 The Journal of biological chemistry
The interrelation between DNA synthesis and various DNA polymerase activities in synchronized HeLa cells. Spadari S 1974 Journal of molecular biology

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