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Gu Z

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Publications:

Title Authors Year Journal
Selection of resistance-conferring mutations in HIV-1 by the nucleoside reverse transcriptase inhibitors (+/-)dOTC and (+/-)dOTFC. Gu Z 2000 Antiviral chemistry & chemotherapy
Mechanism of action and in vitro activity of 1',3'-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants. Gu Z 1999 Antimicrobial agents and chemotherapy
Endogenous reverse transcriptase assays reveal synergy between combinations of the M184V and other drug resistance-conferring mutations in interactions with nucleoside analog triphosphates. Gu Z 1998 Journal of molecular biology
In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Gu Z 1996 Antiviral research
Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2'-dideoxy-3'-thiacytidine by mutated M184V human immunodeficiency virus type 1. Gu Z 1996 J Virol
The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase. Gu Z 1996 The Journal of biological chemistry
Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substitution in 3TC-resistant HIV-1 reverse transcriptase. Gu Z 1996 AIDS (London, England)
Resistance to (-)-2',3'-dideoxy-3'-thiacytidine (3TC) in HIV-1 isolated from paediatric patients. Gu Z 1996 Antiviral therapy
Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase. Gu Z 1996 Science (New York, N.Y.)
Studies of neutralizing monoclonal antibody to human immunodeficiency virus type 1 reverse transcriptase: antagonistic and synergistic effects in reactions performed in the presence of nucleoside and nonnucleoside inhibitors, respectively. Gu Z 1996 Journal of virology
Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase. Gu Z 1996 Protein expression and purification
Effects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNA. Gu Z 1996 Journal of virology
Targeting HIV reverse transcriptase in novel ways. Gu Z 1995 Nature medicine
Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2',3'-dideoxycytidine 5'-triphosphate and other drugs. Gu Z 1995 Proceedings of the National Academy of Sciences of the United States of America
[Molecular basis and clinical significance of HIV-1 resistance to nucleoside compounds]. Gu Z 1995 Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
Effects of non-nucleoside inhibitors of human immunodeficiency virus type 1 in cell-free recombinant reverse transcriptase assays. Gu Z 1995 The Journal of biological chemistry
Inhibition of human immunodeficiency virus type 1 multiplication by transforming growth factor beta 1 and AZT in HIV-1-infected myeloid cells. Gu Z 1995 Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine. Gu Z 1995 Antimicrobial agents and chemotherapy
Development of HIV-1 resistance to (-)2'-deoxy-3'-thiacytidine in patients with AIDS or advanced AIDS-related complex. Gu Z 1995 AIDS (London, England)
Comparison of cord blood and peripheral blood mononuclear cells as targets for viral isolation and drug sensitivity studies involving human immunodeficiency virus type 1. Gu Z 1994 Journal of clinical microbiology
Identification of novel mutations that confer drug resistance in the human immunodeficiency virus polymerase gene. Gu Z 1994 Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine. Gu Z 1994 Antimicrobial agents and chemotherapy
The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2', 3'-dideoxycytidine, 2',3'-dideoxy-3'-thiacytidine, and 2',3'-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro. Gu Z 1994 The Journal of biological chemistry
Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction. Gu Z 1994 The Journal of biological chemistry
Clinical correlates and molecular basis of HIV drug resistance. Gu Z 1993 Journal of acquired immune deficiency syndromes
The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine. Gu Z 1993 Antimicrob Agents Chemother
Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine. Gu Z 1992 J Virol

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