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Ding J

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Publications:

Title Authors Year Journal
Yeast telomerase subunit Est1p has guanine quadruplex-promoting activity that is required for telomere elongation. Ding J 2010 Nature structural & molecular biology
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Ding J 2004 Nature structural & molecular biology
Steered molecular dynamics simulation on the binding of NNRTI to HIV-1 RT. Ding J 2003 Biophysical journal
Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design. Ding J 2003 Nucleic acids research
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. Ding J 2001 The EMBO journal
Molecular dynamics of HIV-1 reverse transcriptase indicates increased flexibility upon DNA binding. Ding J 2001 Proteins
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. Ding J 2001 Journal of molecular biology
Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site. Ding J 1999 Chemistry & biology
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids. Ding J 1999 Proceedings of the National Academy of Sciences of the United States of America
Major subdomain rearrangement in HIV-1 reverse transcriptase simulated by molecular dynamics. Ding J 1999 Proteins
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance. Ding J 1998 Journal of molecular biology
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution. Ding J 1998 Journal of molecular biology
Protein-nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer. Ding J 1997 Biopolymers
Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms. Ding J 1996 Structure (London, England : 1993)
Targeting HIV reverse transcriptase for anti-AIDS drug design: structural and biological considerations for chemotherapeutic strategies. Ding J 1996 Drug design and discovery
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. Ding J 1996 Journal of molecular biology
Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution. Ding J 1995 Structure (London, England : 1993)
Structures of DNA and RNA polymerases and their interactions with nucleic acid substrates. Ding J 1995 Current opinion in structural biology
Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase. Ding J 1995 Biochemistry
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors. Ding J 1995 Nat Struct Biol
Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not. Ding J 1994 Proceedings of the National Academy of Sciences of the United States of America
Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance. Ding J 1994 Journal of molecular biology
Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase. Ding J 1994 Antimicrobial agents and chemotherapy
Buried surface analysis of HIV-1 reverse transcriptase p66/p51 heterodimer and its interaction with dsDNA template/primer. Ding J 1994 Journal of molecular recognition : JMR
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Ding J 1993 Proceedings of the National Academy of Sciences of the United States of America
Structure of HIV-1 reverse transcriptase/DNA complex at 7 A resolution showing active site locations. Ding J 1992 Nature

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