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Brown NC

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Publications:

Title Authors Year Journal
7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. Brown NC 2011 Bioorganic & medicinal chemistry letters
Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. Brown NC 2006 J Med Chem
Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and Gram-positive bacterial growth. Brown NC 2003 J Med Chem
DNA polymerase III of Enterococcus faecalis: expression and characterization of recombinant enzymes encoded by the polC and dnaE genes. Brown NC 2003 Protein Expr Purif
In vitro antimicrobial activities of novel anilinouracils which selectively inhibit DNA polymerase III of gram-positive bacteria. Brown NC 2000 Antimicrob Agents Chemother
6-Anilinouracil-based inhibitors of Bacillus subtilis DNA polymerase III: antipolymerase and antimicrobial structure-activity relationships based on substitution at uracil N3. Brown NC 1999 J Med Chem
Inhibitors of DNA polymerase III as novel antimicrobial agents against gram-positive eubacteria. Brown NC 1999 Antimicrob Agents Chemother
DNA polymerase III of Gram-positive eubacteria is a zinc metalloprotein conserving an essential finger-like domain. Brown NC 1998 Biochemistry
The 3'-5' exonuclease site of DNA polymerase III from gram-positive bacteria: definition of a novel motif structure. Brown NC 1995 Gene
Purification of DNA polymerase III of gram-positive bacteria. Brown NC 1995 Methods in enzymology
DNA polymerase III of Mycoplasma pulmonis: isolation and characterization of the enzyme and its structural gene, polC. Brown NC 1994 Molecular microbiology
Localization of the exonuclease and polymerase domains of Bacillus subtilis DNA polymerase III. Brown NC 1992 Gene
Overproduction and purification of Bacillus subtilis DNA polymerase III. Brown NC 1992 Protein Expr Purif
The molecular mechanism of inhibition of alpha-type DNA polymerases by N2-(butylphenyl)dGTP and 2-(butylanilino)dATP: variation in susceptibility to polymerization. Brown NC 1991 Nucleic acids research
Bacillus subtilis DNA polymerase III: complete sequence, overexpression, and characterization of the polC gene. Brown NC 1991 Gene
Development of novel inhibitor probes of DNA polymerase III based on dGTP analogs of the HPUra type: base, nucleoside and nucleotide derivatives of N2-(3,4-dichlorobenzyl)guanine. Brown NC 1990 Nucleic acids research
Carbonyldiphosphonate, a selective inhibitor of mammalian DNA polymerase delta. Brown NC 1989 Biochemistry
The cloned polC gene of Bacillus subtilis: characterization of the azp12 mutation and controlled in vitro synthesis of active DNA polymerase III. Brown NC 1989 Gene
Calcium-dependent calmodulin-binding proteins associated with mammalian DNA polymerase alpha. Brown NC 1988 Biochimica et biophysica acta
Mammalian DNA polymerase alpha: a replication-competent holoenzyme form from calf thymus. Brown NC 1987 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. Brown NC 1986 J Med Chem
Purification and characterization of DNA polymerase alpha of Chinese hamster ovary cells. Brown NC 1985 Mol Cell Biochem
Elucidation of the mechanism of selective inhibition of mammalian DNA polymerase alpha by 2-butylanilinopurines: development and characterization of 2-(p-n-butylanilino)adenine and its deoxyribonucleotides. Brown NC 1985 Nucleic acids research
Butylphenyl dGTP: a selective and potent inhibitor of mammalian DNA polymerase alpha. Brown NC 1984 Nucleic acids research
Design and characterization of N2-arylaminopurines which selectively inhibit replicative DNA synthesis and replication-specific DNA polymerases: guanine derivatives active on mammalian DNA polymerase alpha and bacterial DNA polymerase III. Brown NC 1982 Nucleic acids research
Butylanilinouracil: a selective inhibitor of HeLa cell DNA synthesis and HeLa cell DNA polymerase alpha. Brown NC 1980 Nucleic acids research
Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. Brown NC 1980 J Med Chem
Antibody to B. subtilis DNA polymerase III: use in enzyme purification and examination of homology among replication-specific DNA polymerases. Brown NC 1979 Nucleic acids research
Bacillus subtilis dnaF: a mutation of the gene specifying the structure of DNA polymerase III. Brown NC 1978 Mol Gen Genet
Inhibitors of Bacillus subtilis DNA polymerase III. 6-(arylalkylamino)uracils and 6-anilinouracils. Brown NC 1977 J Med Chem
Inhibitors of Bacillus subtilis DNA polymerase III. Structure-activity relationships of 6-(phenylhydrazino)uracils. Brown NC 1977 J Med Chem
Bacillus subtilis DNA polymerase III is required for the replication of DNA of bacteriophages SPP-1 and phi 105. Brown NC 1977 J Virol

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