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de Vega M

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Publications:

Title Authors Year Journal
Dual Role of φ29 DNA Polymerase Lys529 in Stabilisation of the DNA Priming-Terminus and the Terminal Protein-Priming Residue at the Polymerisation Site. de Vega M 2013 PloS one
DNA stabilization at the Bacillus subtilis PolX core--a binding model to coordinate polymerase, AP-endonuclease and 3'-5' exonuclease activities. de Vega M 2012 Nucleic acids research
The essential role of the 3' terminal template base in the first steps of protein-primed DNA replication. de Vega M 2012 PloS one
Terminal protein-primed amplification of heterologous DNA with a minimal replication system based on phage {Phi}29. de Vega M 2011 Proceedings of the National Academy of Sciences of the United States of America
Involvement of residues of the 29 terminal protein intermediate and priming domains in the formation of a stable and functional heterodimer with the replicative DNA polymerase. de Vega M 2011 Nucleic acids research
Improvement of phi29 DNA polymerase amplification performance by fusion of DNA binding motifs. de Vega M 2010 Proceedings of the National Academy of Sciences of the United States of America
Intrinsic apurinic/apyrimidinic (AP) endonuclease activity enables Bacillus subtilis DNA polymerase X to recognize, incise, and further repair abasic sites. de Vega M 2010 Proceedings of the National Academy of Sciences of the United States of America
phi29 DNA polymerase active site: role of residue Val250 as metal-dNTP complex ligand and in protein-primed initiation. de Vega M 2010 Journal of molecular biology
Involvement of the TPR2 subdomain movement in the activities of phi29 DNA polymerase. de Vega M 2009 Nucleic acids research
Functional importance of bacteriophage phi29 DNA polymerase residue Tyr148 in primer-terminus stabilisation at the 3'-5' exonuclease active site. de Vega M 2009 Journal of molecular biology
Characterization of a Bacillus subtilis 64-kDa DNA polymerase X potentially involved in DNA repair. de Vega M 2008 Journal of molecular biology
Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. de Vega M 2008 Nucleic acids research
Enzymatic synthesis of structure-free DNA with pseudo-complementary properties. de Vega M 2008 Nucleic acids research
Phage phi29 and Nf terminal protein-priming domain specifies the internal template nucleotide to initiate DNA replication. de Vega M 2008 Proceedings of the National Academy of Sciences of the United States of America
The bacteriophage phi29 DNA polymerase. de Vega M 2008 IUBMB Life
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases. de Vega M 2007 The EMBO journal
Involvement of phage phi29 DNA polymerase and terminal protein subdomains in conferring specificity during initiation of protein-primed DNA replication. de Vega M 2007 Nucleic acids research
A highly conserved Tyrosine residue of family B DNA polymerases contributes to dictate translesion synthesis past 8-oxo-7,8-dihydro-2'-deoxyguanosine. de Vega M 2007 Nucleic acids research
Involvement of phi29 DNA polymerase thumb subdomain in the proper coordination of synthesis and degradation during DNA replication. de Vega M 2006 Nucleic acids research
The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition. de Vega M 2006 The EMBO journal
Functional characterization of highly processive protein-primed DNA polymerases from phages Nf and GA-1, endowed with a potent strand displacement capacity. de Vega M 2006 Nucleic acids research
A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity. de Vega M 2005 Proceedings of the National Academy of Sciences of the United States of America
Involvement of the "linker" region between the exonuclease and polymerization domains of phi29 DNA polymerase in DNA and TP binding. de Vega M 2005 Gene
Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29. de Vega M 2004 Molecular cell
phi29 DNA polymerase-terminal protein interaction. Involvement of residues specifically conserved among protein-primed DNA polymerases. de Vega M 2004 Journal of molecular biology
A conserved insertion in protein-primed DNA polymerases is involved in primer terminus stabilisation. de Vega M 2003 Journal of molecular biology
phi29 DNA polymerase residue Phe128 of the highly conserved (S/T)Lx(2)h motif is required for a stable and functional interaction with the terminal protein. de Vega M 2003 Journal of molecular biology
phi 29 DNA polymerase residue Leu384, highly conserved in motif B of eukaryotic type DNA replicases, is involved in nucleotide insertion fidelity. de Vega M 2003 The Journal of biological chemistry
Phi29 DNA polymerase residues Tyr59, His61 and Phe69 of the highly conserved ExoII motif are essential for interaction with the terminal protein. de Vega M 2002 Nucleic acids research
An aspartic acid residue in TPR-1, a specific region of protein-priming DNA polymerases, is required for the functional interaction with primer terminal protein. de Vega M 2000 Journal of molecular biology
Phage phi 29 DNA polymerase residues involved in the proper stabilisation of the primer-terminus at the 3'-5' exonuclease active site. de Vega M 2000 Journal of molecular biology
Processive proofreading and the spatial relationship between polymerase and exonuclease active sites of bacteriophage phi29 DNA polymerase. de Vega M 1999 Journal of molecular biology
phi29 DNA polymerase residue Ser122, a single-stranded DNA ligand for 3'-5' exonucleolysis, is required to interact with the terminal protein. de Vega M 1998 The Journal of biological chemistry
Mutational analysis of phi29 DNA polymerase residues acting as ssDNA ligands for 3'-5' exonucleolysis. de Vega M 1998 Journal of molecular biology
An invariant lysine residue is involved in catalysis at the 3'-5' exonuclease active site of eukaryotic-type DNA polymerases. de Vega M 1997 Journal of molecular biology
Primer-terminus stabilization at the 3'-5' exonuclease active site of phi29 DNA polymerase. Involvement of two amino acid residues highly conserved in proofreading DNA polymerases. de Vega M 1996 The EMBO journal
Terminal protein-primed DNA amplification. de Vega M 1994 Proceedings of the National Academy of Sciences of the United States of America

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