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Kool ET

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Publications:

Title Authors Year Journal
Probing the interaction of archaeal DNA polymerases with deaminated bases using X-ray crystallography and non-hydrogen bonding isosteric base analogues. Kool ET 2010 Biochemistry
Base pair hydrogen bonds are essential for proofreading selectivity by the human mitochondrial DNA polymerase. Kool ET 2008 The Journal of biological chemistry
Importance of hydrogen bonding for efficiency and specificity of the human mitochondrial DNA polymerase. Kool ET 2008 The Journal of biological chemistry
Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection. Kool ET 2007 Journal of molecular biology
Steric and electrostatic effects in DNA synthesis by the SOS-induced DNA polymerases II and IV of Escherichia coli. Kool ET 2007 Biochemistry
Dynamics of nucleotide incorporation: snapshots revealed by 2-aminopurine fluorescence studies. Kool ET 2006 Biochemistry
Functional evidence for a small and rigid active site in a high fidelity DNA polymerase: probing T7 DNA polymerase with variably sized base pairs. Kool ET 2006 The Journal of biological chemistry
Varying DNA base-pair size in subangstrom increments: evidence for a loose, not large, active site in low-fidelity Dpo4 polymerase. Kool ET 2006 Biochemistry
Remarkable sensitivity to DNA base shape in the DNA polymerase active site. Kool ET 2006 Angew Chem Int Ed Engl
DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics. Kool ET 2006 Biochemistry
Fluorous base-pairing effects in a DNA polymerase active site. Kool ET 2005 Chemistry
Probing the active site tightness of DNA polymerase in subangstrom increments. Kool ET 2005 Proceedings of the National Academy of Sciences of the United States of America
Efficient isothermal expansion of human telomeric and minisatellite repeats by Thermococcus litoralis DNA polymerase. Kool ET 2005 Nucleic acids research
Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase kappa. Kool ET 2005 Molecular and cellular biology
Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Kool ET 2004 Molecular and cellular biology
Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta. Kool ET 2003 Molecular and cellular biology
Pyrene nucleotide as a mechanistic probe: evidence for a transient abasic site-like intermediate in the bypass of dipyrimidine photoproducts by T7 DNA polymerase. Kool ET 2000 Biochemistry
Importance of terminal base pair hydrogen-bonding in 3'-end proofreading by the Klenow fragment of DNA polymerase I. Kool ET 2000 Biochemistry

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