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Loregian A

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Publications:

Title Authors Year Journal
Design, Synthesis, and Evaluation of WC5 Analogues as Inhibitors of Human Cytomegalovirus Immediate-Early 2 Protein, a Promising Target for Anti-HCMV Treatment. Loregian A 2013 ChemMedChem
The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication. Loregian A 2010 Journal of virology
The flexible loop of the human cytomegalovirus DNA polymerase processivity factor ppUL44 is required for efficient DNA binding and replication in cells. Loregian A 2009 J Virol
Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84. Loregian A 2009 J Virol
Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells. Loregian A 2008 Journal of virology
Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism. Loregian A 2007 Nucleic acids research
Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44. Loregian A 2006 The Journal of biological chemistry
Cloning, expression, and functional characterization of the equine herpesvirus 1 DNA polymerase and its accessory subunit. Loregian A 2006 J Virol
Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses. Loregian A 2006 Antiviral research
Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase. Loregian A 2006 Chemistry & biology
Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44. Loregian A 2004 J Virol
The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer. Loregian A 2004 Molecular cell
Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit. Loregian A 2004 J Virol
Inhibition of human cytomegalovirus DNA polymerase by C-terminal peptides from the UL54 subunit. Loregian A 2003 J Virol
The catalytic subunit of herpes simplex virus type 1 DNA polymerase contains a nuclear localization signal in the UL42-binding region. Loregian A 2000 Virology
Use of Vibrio spp. for expression of Escherichia coli enterotoxin B subunit fusion proteins: purification and characterization of a chimera containing a C-terminal fragment of DNA polymerase from herpes simplex virus type 1. Loregian A 1996 Protein Expr Purif
Construction of a fusion protein between B subunit of E. coli heat-labile enterotoxin and the C-terminus of herpes simplex virus-DNA polymerase. Loregian A 1995 Biochem Soc Trans

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