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Eoff RL

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Publications:

Title Authors Year Journal
Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Eoff RL 2013 Chemical research in toxicology
Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2'-deoxyadenosine. Eoff RL 2013 Biochemistry
Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein. Eoff RL 2012 The Journal of biological chemistry
A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. Eoff RL 2012 PloS one
Differential Furanose Selection in the Active Sites of Archaeal DNA Polymerases Probed by Fixed-Conformation Nucleotide Analogues. Eoff RL 2012 Biochemistry
A nucleotide analogue induced gain of function corrects the error-prone nature of human DNA polymerase iota. Eoff RL 2012 Journal of the American Chemical Society
Roles of the Four DNA Polymerases of the Crenarchaeon Sulfolobus solfataricus and Accessory Proteins in DNA Replication. Eoff RL 2011 The Journal of biological chemistry
Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Eoff RL 2010 Angewandte Chemie (International ed. in English)
Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. Eoff RL 2010 Acta Crystallogr Sect F Struct Biol Cryst Commun
Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts. Eoff RL 2009 The Journal of biological chemistry
Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct. Eoff RL 2009 The Journal of biological chemistry
Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct. Eoff RL 2009 Biochemistry
Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4. Eoff RL 2009 The Journal of biological chemistry
Kinetic analysis of base-pairing preference for nucleotide incorporation opposite template pyrimidines by human DNA polymerase iota. Eoff RL 2009 Journal of molecular biology
Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one . Eoff RL 2009 Biochemistry
Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes. Eoff RL 2009 The Journal of biological chemistry
Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch. Eoff RL 2009 The Journal of biological chemistry
Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4. Eoff RL 2007 The Journal of biological chemistry
Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene. Eoff RL 2007 The Journal of biological chemistry
Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. Eoff RL 2007 The Journal of biological chemistry
Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred. Eoff RL 2007 The Journal of biological chemistry
Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4. Eoff RL 2006 Biochemistry

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