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Horton JK

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Publications:

Title Authors Year Journal
Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. Horton JK 2013 DNA repair
Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity. Horton JK 2013 Frontiers in oncology
Interaction between DNA Polymerase β and BRCA1. Horton JK 2013 PloS one
Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts. Horton JK 2012 PloS one
Base excision repair and design of small molecule inhibitors of human DNA polymerase beta. Horton JK 2010 Cell Mol Life Sci
DNA polymerase beta-dependent long patch base excision repair in living cells. Horton JK 2010 DNA repair
DNA polymerase beta and PARP activities in base excision repair in living cells. Horton JK 2009 DNA repair
XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Horton JK 2008 Cell research
HMGB1 is a cofactor in mammalian base excision repair. Horton JK 2007 Molecular cell
Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines. Horton JK 2007 DNA repair
Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency. Horton JK 2007 DNA repair
Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death. Horton JK 2005 DNA repair
DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. Horton JK 2005 The Journal of biological chemistry
Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure. Horton JK 2005 The Journal of biological chemistry
REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast. Horton JK 2005 DNA repair
Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping. Horton JK 2004 The Journal of biological chemistry
Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions. Horton JK 2003 DNA repair
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. Horton JK 2003 The Journal of biological chemistry
Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage. Horton JK 2002 DNA repair
Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen. Horton JK 2002 The Journal of biological chemistry
Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair. Horton JK 2001 The Journal of biological chemistry
DNA polymerase beta and mammalian base excision repair. Horton JK 2000 Cold Spring Harbor symposia on quantitative biology
Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair. Horton JK 2000 The Journal of biological chemistry
Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines. Horton JK 1998 Nucleic acids research
Requirement of mammalian DNA polymerase-beta in base-excision repair. Horton JK 1996 Nature
Strategic down-regulation of DNA polymerase beta by antisense RNA sensitizes mammalian cells to specific DNA damaging agents. Horton JK 1995 Nucleic acids research

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