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Arion D

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Publications:

Title Authors Year Journal
The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1. Arion D 2005 The Journal of biological chemistry
Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation. Arion D 2004 The international journal of biochemistry & cell biology
Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors. Arion D 2002 Molecular pharmacology
Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones. Arion D 2002 The Journal of biological chemistry
Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase. Arion D 2000 The Journal of biological chemistry
Mutational analysis of Lys65 of HIV-1 reverse transcriptase. Arion D 2000 Biochem J
The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis. Arion D 2000 J Virol
Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs). Arion D 2000 Cellular and molecular life sciences : CMLS
The thiocarboxanilide nonnucleoside inhibitor UC781 restores antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus type 1. Arion D 1999 Antimicrobial agents and chemotherapy
HIV resistance to zidovudine: the role of pyrophosphorolysis. Arion D 1999 Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Arion D 1998 Biochemistry
Physicochemical and biochemical properties of 2',5'-linked RNA and 2',5'-RNA:3',5'-RNA "hybrid" duplexes. Arion D 1998 Biochemistry
Inhibitory potency of R-region specific antisense oligonucleotides against in vitro DNA polymerization and template-switching reactions catalysed by HIV-1 reverse transcriptase. Arion D 1997 Int J Biochem Cell Biol
Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone. Arion D 1997 Biochemistry
The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase. Arion D 1996 The Journal of biological chemistry
Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase. Arion D 1996 Protein expression and purification
Differences in the inhibition of human immunodeficiency virus type 1 reverse transcriptase DNA polymerase activity by analogs of nevirapine and [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1", 2"-oxathiole-2",2"-dioxide] (TSAO). Arion D 1996 Molecular pharmacology
HIV-1 reverse transcriptase shows no specificity for the binding of primer tRNA(Lys3). Arion D 1996 Biochemical and biophysical research communications
Synergistic inhibition of HIV-1 reverse transcriptase DNA polymerase activity and virus replication in vitro by combinations of carboxanilide nonnucleoside compounds. Arion D 1995 Biochemistry

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