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Human DNA polymerase kappa synthesizes DNA with extraordinarily low fidelity. |
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A sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA. |
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High fidelity DNA synthesis by the Thermus aquaticus DNA polymerase. |
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DNA polymerase I and a protein complex bind specifically to E. coli palindromic unit highly repetitive DNA: implications for bacterial chromosome organization. |
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Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase. |
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Purification and characterization of a DNA polymerase from the cyanobacterium Anacystis nidulans R2. |
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The inhibition of mitochondrial DNA polymerase gamma from animal cells by intercalating drugs. |
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Polbase: a repository of biochemical, genetic and structural information about DNA polymerases. |
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Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin. |
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Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. |
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Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. |
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Adenovirus DNA polymerase: domain organisation and interaction with preterminal protein. |
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The N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions. |
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DNA and RNA-DNA annealing activity associated with the tau subunit of the Escherichia coli DNA polymerase III holoenzyme. |
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N4-Methoxydeoxycytidine triphosphate is in the imino tautomeric form and substitutes for deoxythymidine triphosphate in primed poly d[A-T] synthesis with E. coli DNA polymerase I. |
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The 3'-5' proofreading exonuclease of archaeal family-B DNA polymerase hinders the copying of template strand deaminated bases. |
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DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D. |
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A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis. |
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REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo. |
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Design and characterization of N2-arylaminopurines which selectively inhibit replicative DNA synthesis and replication-specific DNA polymerases: guanine derivatives active on mammalian DNA polymerase alpha and bacterial DNA polymerase III. |
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In vitro conversion of MVM parvovirus single-stranded DNA to the replicative form by DNA polymerase alpha from Ehrlich ascites tumour cells. |
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The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit. |
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The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells. |
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Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity. |
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Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. |
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Evidence implying DNA polymerase beta function in excision repair. |
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Unique requirements for template primers of DNA polymerase beta from rat ascites hepatoma AH130 cells. |
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Replication of poly dA and poly rA by a drosophila DNA polymerase. |
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Thermodynamics of the binding of Thermus aquaticus DNA polymerase to primed-template DNA. |
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MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon. |
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Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota. |
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The N-terminal region of DNA polymerase delta catalytic subunit is necessary for holoenzyme function. |
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Endogenous DNA polymerase activity in fractionated rat lever chromatin. |
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Purification and characterization of DNA polymerase from the archaebacterium Sulfolobus acidocaldarius. |
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Levels of DNA polymerase-alpha and beta in normal and xeroderma pigmentosum fibroblasts. |
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Synthesis and properties of oligonucleotides containing 5-formyl-2'-deoxycytidine: in vitro DNA polymerase reactions on DNA templates containing 5-formyl-2'-deoxycytidine. |
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Alterations of DNA-dependent DNA polymerase activities in the immature quail oviduct in response to estrogen stimulation. |
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Escherichia coli RNA and DNA polymerase bypass of dihydrouracil: mutagenic potential via transcription and replication. |
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The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon. |
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The second subunit of DNA polymerase III (delta) is encoded by the HYS2 gene in Saccharomyces cerevisiae. |
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Promiscuous mismatch extension by human DNA polymerase lambda. |
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The use of large-fragment DNA polymerase I improves the DNAse dependence of the in situ nick-translation procedure. |
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Characterization of a stable, major DNA polymerase alpha species devoid of DNA primase activity. |
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Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. |
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Sequence dependence for bypass of thymine glycols in DNA by DNA polymerase I. |
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Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. |
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DNA polymerase beta is required for efficient DNA strand break repair induced by methyl methanesulfonate but not by hydrogen peroxide. |
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Proteolysis of the human DNA polymerase epsilon catalytic subunit by caspase-3 and calpain specifically during apoptosis. |
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Domain specific interaction in the XRCC1-DNA polymerase beta complex. |
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Isolation and characterisation of the cDNA encoding a glycosylated accessory protein of pea chloroplast DNA polymerase. |
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Non-homologous recombination mediated by Thermus aquaticus DNA polymerase I. Evidence supporting a copy choice mechanism. |
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Synthesis and evaluation of oligodeoxyribonucleotides containing an aryl(trifluoromethyl)diazirine moiety as the cross-linking probe: photoaffinity labeling of mammalian DNA polymerase beta. |
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Organization and nucleotide sequence of the DNA polymerase gene from the archaeon Pyrococcus furiosus. |
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Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae. |
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Aphidicolin resistance in herpes simplex virus type I reveals features of the DNA polymerase dNTP binding site. |
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A trimeric DNA polymerase complex increases the native replication processivity. |
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Characterization of 3'----5' exonuclease associated with DNA polymerase of silkworm nuclear polyhedrosis virus. |
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Characterization of the DNA polymerase requirement of human base excision repair. |
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Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts. |
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DNA polymerase III chi subunit ties single-stranded DNA binding protein to the bacterial replication machinery. |
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Fission yeast with DNA polymerase delta temperature-sensitive alleles exhibits cell division cycle phenotype. |
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An autoradiographic demonstration of nuclear DNA replication by DNA polymerase alpha and of mitochondrial DNA synthesis by DNA polymerase gamma. |
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Characterization of DNA synthesis catalyzed by bacteriophage T4 replication complexes reconstituted on synthetic circular substrates. |
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Plasmid-based lacZalpha assay for DNA polymerase fidelity: application to archaeal family-B DNA polymerase. |
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Identification of a DNA polymerase beta-like form in Drosophila melanogaster adult flies. |
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Stopping the DNA polymerase activity at a specific site with a dideoxyoligonucleotide: selective labelling of single stranded circular DNA. |
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PCNA-induced DNA synthesis past cis-syn and trans-syn-I thymine dimers by calf thymus DNA polymerase delta in vitro. |
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Isolation of the catalytic core of DNA polymerase alpha from rabbit bone marrow. |
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Sites of termination of in vitro DNA synthesis on cis-diamminedichloroplatinum(II) treated single-stranded DNA: a comparison between E. coli DNA polymerase I and eucaryotic DNA polymerases alpha. |
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Characterization of a Mr = 56,000 polypeptide associated with 10S DNA polymerase alpha purified from calf thymus using monoclonal antibody. |
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Response of human DNA polymerase iota to DNA lesions. |
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The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. |
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Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha. |
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Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids. |
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DNA polymerase proofreading: active site switching catalyzed by the bacteriophage T4 DNA polymerase. |
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Functional characterization of highly processive protein-primed DNA polymerases from phages Nf and GA-1, endowed with a potent strand displacement capacity. |
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The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient. |
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A dynamic model for replication protein A (RPA) function in DNA processing pathways. |
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Factor D is a selective single-stranded oligodeoxythymidine binding protein. |
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Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates. |
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A DNA polymerase activity is associated with Cauliflower Mosaic Virus. |
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Synthesis of novel poly(dG)-poly(dG)-poly(dC) triplex structure by Klenow exo- fragment of DNA polymerase I. |
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T4 DNA polymerase (3'-5') exonuclease, an enzyme for the detection and quantitation of stable DNA lesions: the ultraviolet light example. |
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Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pH. |
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The influence of 3TC-resistance mutations E89G and M184V in the human immunodeficiency virus reverse transcriptase on mispair extension efficiency. |
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Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus. |
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Multiple primer extension by DNA polymerase on a novel plastic DNA array coated with a biocompatible polymer. |
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The use of native T7 DNA polymerase for site-directed mutagenesis. |
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Structural homology among calf thymus alpha-polymerase polypeptides. |
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DNA polymerase alpha and beta in the California urchin. |
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Does butylphenyl-deoxyguanosine triphosphate differentially inhibit DNA polymerase alpha and delta activities in permeabilized HeLa cells? |
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Nuclear DNA polymerase beta from Leishmania infantum. Cloning, molecular analysis and developmental regulation. |
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Template specific inhibitor of mammalian DNA polymerases. |
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The mitochondrial DNA polymerase as a target of oxidative damage. |
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The role of DNA polymerase activity in human non-homologous end joining. |
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Arg660Ser mutation in Thermus aquaticus DNA polymerase I suppresses T-->C transitions: implication of wobble base pair formation at the nucleotide incorporation step. |
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Mitochondrial DNA polymerase gamma is expressed and translated in the absence of mitochondrial DNA maintenance and replication. |
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DNA strand transfer catalyzed by the 5'-3' exonuclease domain of Escherichia coli DNA polymerase I. |
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A novel mechanism of selectivity against AZT by the human mitochondrial DNA polymerase. |
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The herpes simplex virus type 1 DNA polymerase processivity factor, UL42, does not alter the catalytic activity of the UL9 origin-binding protein but facilitates its loading onto DNA. |
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Unnatural imidazopyridopyrimidine:naphthyridine base pairs: selective incorporation and extension reaction by Deep Vent (exo- ) DNA polymerase. |
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Duplex strand joining reactions catalyzed by vaccinia virus DNA polymerase. |
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Synthesis and properties of defined DNA oligomers containing base mispairs involving 2-aminopurine. |
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Cloning of the gene for the 73 kD subunit of the DNA polymerase alpha primase of Drosophila melanogaster. |
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Clustering of Alpers disease mutations and catalytic defects in biochemical variants reveal new features of molecular mechanism of the human mitochondrial replicase, Pol {gamma} |
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Critical amino acids in Escherichia coli UmuC responsible for sugar discrimination and base-substitution fidelity. |
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A novel DNA nuclease is stimulated by association with the GINS complex. |
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Detection of an epitope, not required for polymerization, that is conserved between E.coli DNA polymerases I and III and bacteriophage T4 DNA polymerase. |
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Mismatched nucleotides may facilitate expansion of trinucleotide repeats in genetic diseases. |
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Different structural states in oligonucleosomes are required for early versus late steps of base excision repair. |
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Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. |
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8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha. |
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Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. |
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Roles of Saccharomyces cerevisiae DNA polymerases Poleta and Polzeta in response to irradiation by simulated sunlight. |
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Deletion errors generated during replication of CAG repeats. |
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Site specific mutagenesis: insertion of single noncomplementary nucleotides at specified sites by error-directed DNA polymerization. |
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Identification of DNA replication and cell cycle proteins that interact with PCNA. |
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Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis. |
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Mammalian DNA helicase. |
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REV1 and polymerase {zeta} facilitate homologous recombination repair. |
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The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ |
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Pol β associated complex and base excision repair factors in mouse fibroblasts. |
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Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint. |
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DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion. |
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DNA stabilization at the Bacillus subtilis PolX core--a binding model to coordinate polymerase, AP-endonuclease and 3'-5' exonuclease activities. |
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Ribonucleotides and manganese ions improve non-homologous end joining by human Polμ |
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Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion. |
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Paradoxical effect of Simian virus 40 enhancer on the function of mouse DNA polymerase beta gene promoter. |
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Transcriptional regulation of the Drosophila-raf proto-oncogene by the DNA replication-related element (DRE)/DRE-binding factor (DREF) system. |
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Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A. |
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A high-throughput and quantitative method to assess the mutagenic potential of translesion DNA synthesis. |
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Reconstitution of recombination-associated DNA synthesis with human proteins. |
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Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1. |
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Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase. |
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A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks. |
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A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli. |
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Observations on template-specific conditions for DNA synthesis by avian myeloblastosis virus DNA polymerase. |
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Alteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamics. |
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Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, epsilon, θ and β reveals a highly flexible arrangement of the proofreading domain. |
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DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation. |
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2013 |
DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures. |
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2013 |
Carcinogenic adducts induce distinct DNA polymerase binding orientations. |
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2013 |
A cyclobutane thymine-N4-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis. |
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Sulfolobus chromatin proteins modulate strand displacement by DNA polymerase B1. |
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2013 |
The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability. |
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2012 |
Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage. |
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PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage. |
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2014 |
Nucleotide selection by the Y-family DNA polymerase Dpo4 involves template translocation and misalignment. |
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2014 |
Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines. |
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2013 |
Real-time single-molecule studies of the motions of DNA polymerase fingers illuminate DNA synthesis mechanisms. |
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2015 |
Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta. |
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2001 |