Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links. |
Yamanaka K, Minko IG, Takata K, Kolbanovskiy A, Kozekov ID, Wood RD, Rizzo CJ, Lloyd RS |
2010 |
Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). |
Christov PP, Petrova KV, Shanmugam G, Kozekov ID, Kozekova A, Guengerich FP, Stone MP, Rizzo CJ |
2010 |
Polymerization past the N2-isopropylguanine and the N6-isopropyladenine DNA lesions with the translesion synthesis DNA polymerases eta and iota and the replicative DNA polymerase alpha. |
Perrino FW, Harvey S, Blans P, Gelhaus SL, Lacourse WR, Fishbein JC |
2005 |
The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha. |
Perrino FW, Blans P, Harvey S, Gelhaus SL, McGrath C, Akman SA, Jenkins GS, Lacourse WR, Fishbein JC |
2003 |
Replication past the N5-methyl-formamidopyrimidine lesion of deoxyguanosine by DNA polymerases and an improved procedure for sequence analysis of in vitro bypass products by mass spectrometry. |
Christov PP, Angel KC, Guengerich FP, Rizzo CJ |
2009 |
Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations. |
Wang L, Wu M, Yan SF, Patel DJ, Geacintov NE, Broyde S |
2005 |
Molecular dynamics of a food carcinogen-DNA adduct in a replicative DNA polymerase suggest hindered nucleotide incorporation and extension. |
Zhang L, Shapiro R, Broyde S |
2005 |
Replication of a site-specific trans-8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B(1) adduct by the exonuclease deficient klenow fragment of DNA polymerase I. |
Johnston DS, Stone MP |
2000 |
Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases. |
Stover JS, Chowdhury G, Zang H, Guengerich FP, Rizzo CJ |
2006 |
Translesion synthesis across polycyclic aromatic hydrocarbon diol epoxide adducts of deoxyadenosine by Sulfolobus solfataricus DNA polymerase Dpo4. |
Zang H, Chowdhury G, Angel KC, Harris TM, Guengerich FP |
2006 |
Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine. |
Goodenough AK, Kozekov ID, Zang H, Choi JY, Guengerich FP, Harris TM, Rizzo CJ |
2005 |
Kinetics of nucleotide incorporation opposite polycyclic aromatic hydrocarbon-DNA adducts by processive bacteriophage T7 DNA polymerase. |
Zang H, Harris TM, Guengerich FP |
2005 |
Kinetic Analysis of the Bypass of a Bulky DNA Lesion Catalyzed by Human Y-family DNA Polymerases. |
Sherrer SM, Sanman LE, Xia CX, Bolin ER, Malik CK, Efthimiopoulos G, Basu AK, Suo Z |
2012 |
Low fidelity bypass of O<sup>2</sup>-(3-pyridyl)-4-oxobutylthymine, the most persistent bulky adduct produced by the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by model polymerases. |
A S PG, Krishnegowda G, Suo Z, Amin SG, Spratt TE |
2012 |
Species-specific, P450- and sulfotransferase-mediated novel ring contraction of a naphthyridine-N-oxide compound in cynomolgus monkey. |
Daniels JS, Espina R, Cao K, Yuan H, Lin J, Diamond S, Johnson B, Rodgers J, Prakash S, Unger S, Christ D, Miwa G, Gan LS, Mutlib A |
2007 |
Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family. |
Minko IG, Yamanaka K, Kozekov ID, Kozekova A, Indiani C, O'Donnell ME, Jiang Q, Goodman MF, Rizzo CJ, Lloyd RS |
2008 |
1,N2-Etheno-2'-deoxyguanosine adopts the syn conformation about the glycosyl bond when mismatched with deoxyadenosine. |
Shanmugam G, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP |
2011 |
The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro. |
Christov PP, Chowdhury G, Garmendia CA, Wang F, Stover JS, Elmquist CE, Kozekova A, Angel KC, Turesky RJ, Stone MP, Guengerich FP, Rizzo CJ |
2010 |
Polymerase blockage and misincorporation of dNTPs opposite the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione. |
Kim MS, Guengerich FP |
1998 |
Identification of an Unfolding Intermediate for a DNA Lesion Bypass Polymerase. |
Sherrer SM, Maxwell BA, Pack LR, Fiala KA, Fowler JD, Zhang J, Suo Z |
2012 |
Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV. |
Banerjee S, Christov PP, Kozekova A, Rizzo CJ, Egli M, Stone MP |
2012 |
Accurate and Efficient Bypass of 8,5'-Cyclopurine-2'-Deoxynucleosides by Human and Yeast DNA Polymerase η |
Swanson AL, Wang J, Wang Y |
2012 |
Effects of N2-Alkylguanine, O6-Alkylguanine, and Abasic Lesions on DNA Binding and Bypass Synthesis by the Euryarchaeal B-family DNA Polymerase Vent (exo-). |
Lim S, Song I, Guengerich FP, Choi JY |
2012 |
DNA Polymerase β Gap-filling Translesion DNA Synthesis. |
Chary P, Beard WA, Wilson SH, Lloyd RS |
2012 |
Mutagenic bypass of 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) by DNA polymerase κ in human cells. |
Kamiya H, Kurokawa M |
2012 |
In-vitro replication studies on o(2)-methylthymidine and o(4)-methylthymidine. |
Andersen N, Wang J, Wang P, Jiang Y, Wang Y |
2012 |
Mutagenesis induced by oxidized DNA precursors: roles of Y family DNA polymerases in Escherichia coli. |
Satou K, Yamada M, Nohmi T, Harashima H, Kamiya H |
2005 |
Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. |
Ketkar A, Zafar MK, Maddukuri L, Yamanaka K, Banerjee S, Egli M, Choi JY, Lloyd RS, Eoff RL |
2013 |
Ring-opening of the γ-OH-PdG adduct promotes error-free bypass by the Sulfolobus solfataricus DNA polymerase Dpo4. |
Shanmugam G, Minko IG, Banerjee S, Christov PP, Kozekov ID, Rizzo CJ, Lloyd RS, Egli M, Stone MP |
2013 |