HIV RT L100I

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This page presents all the information in Polbase for HIV RT L100I.

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Mutant of: HIV RT (L100I)

HIV RT L100I is a family RT enzyme from HIV. From the Los Alamos National Labs HIV Mutant database (now offline):|id:376|codon:TTA>ATA|drugs:BHAP U-88204E|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Partially suppresses effects of AZT resistance mutations "From the Los Alamos National Labs HIV Mutant database (now offline):|id:377|codon:TTA>ATA|drugs:BI-RG-587 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:378|codon:TTA>ATA|drugs:DMP-266 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:379|codon:TTA>ATA|drugs:L-697 From the Los Alamos National Labs HIV Mutant database (now offline):|id:380|codon:TTA>ATA|drugs:TIBO R82150|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Suppresses effects of AZT resistance mutations From the Los Alamos National Labs HIV Mutant database (now offline):|id:381|codon:TTA>ATA|drugs:TIBO R82913|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Found in combination with E138K "From the Los Alamos National Labs HIV Mutant database (now offline):|id:382|codon:TTA>ATA|drugs:UC-68 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:383|codon:TTA>ATA|drugs:UC-70 "From the Los Alamos National Labs HIV Mutant database (now offline):|id:384|codon:TTA>ATA|drugs:UC-781|class:HIV-1 Specific RT Inhibitor (NNRTI)|notes:Activity of UC-781 versus L100I "From the Los Alamos National Labs HIV Mutant database (now offline):|id:385|codon:TTA>ATA|drugs:UC-84

Selected Properties for HIV RT L100I:

 3'-5' exo activity 5'-3' exo activity Frameshift Rate Substitution Rate General Error Rate
no data no data no data no data no data
Year Authors Title Results by property
2008 Kalyan Das, Joseph David Bauman, Arthur D Clark, Yulia Volovik Frenkel, Paul J Lewi, Aaron J Shatkin, Stephen H Hughes, Edward Arnold High-resolution structures of HIV-1 r... RT,All properties
2004 Jingshan Ren, Charles E Nichols, Phillip P Chamberlain, Kurt L Weaver, Steven A Short, David K Stammers Crystal structures of HIV-1 reverse t... RT,Associated condition,All properties
2000 L T Bacheler, E D Anton, P Kudish, D Baker, J Bunville, K Krakowski, L Bolling, M Aujay, X V Wang, D Ellis, M F Becker, A L Lasut, H J George, D R Spalding, G Hollis, K Abremski Human immunodeficiency virus type 1 m...
1996 Jan Balzarini, H Pelemans, Stefano Aquaro, CF Perno, Myriam Witvrouw, Dominique Schols, Erik De Clercq, Anna Karlsson Highly favorable antiviral activity a...
1996 Jan Balzarini, W G Brouwer, D C Dao, E M Osika, Erik De Clercq Identification of novel thiocarboxani...
1996 D L Winslow, S Garber, C Reid, H Scarnati, D Baker, M M Rayner, E D Anton Selection conditions affect the evolu...
1995 S D Young, S F Britcher, L O Tran, L S Payne, W C Lumma, T A Lyle, J R Huff, P S Anderson, David B Olsen, Steven S Carroll L-743, 726 (DMP-266): a novel, highly...
1995 Robert W Buckheit, T L Kinjerski, V Fliakas-Boltz, J D Russell, T L Stup, L A Pallansch, W G Brouwer, D C Dao, W A Harrison, R J Schultz Structure-activity and cross-resistan...
1995 Jan Balzarini, María-Jesús Pérez-Pérez, S Vélazquez, Ana San-Félix, María-José Camarasa, Erik De Clercq, Anna Karlsson Suppression of the breakthrough of hu...
1993 Jan Balzarini, Anna Karlsson, María-Jesús Pérez-Pérez, María-José Camarasa, W G Tarpley, Erik De Clercq Treatment of human immunodeficiency v...
1993 V W Byrnes, V V Sardana, W A Schleif, J H Condra, J A Waterbury, J A Wolfgang, W J Long, C L Schneider, A J Schlabach, B S Wolanski Comprehensive mutant enzyme and viral...
1993 John W Mellors, G J Im, Enzo Tramontano, S R Winkler, D J Medina, Ginger E Dutschman, Holly Z Bazmi, G Piras, C J Gonzalez, Yung-Chi Cheng A single conservative amino acid subs...
1993 Jan Balzarini, Anna Karlsson, María-Jesús Pérez-Pérez, L Vrang, J Walbers, Haijiang Zhang, Bo Oberg, A-M Vandamme, María-José Camarasa, Erik De Clercq HIV-1-specific reverse transcriptase ...
1993 Douglas D Richman Resistance of clinical isolates of hu...
1992 M B Vasudevachari, C Battista, H C Lane, M C Psallidopoulos, B Zhao, J Cook, J R Palmer, D L Romero, W G Tarpley, N P Salzman Prevention of the spread of HIV-1 inf...

Version:20241007

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