Utilization of aminopurine deoxynucleoside triphosphate by mutator, antimutator and wild-type DNA polymerases of bacteriophage T4.

Schnaar RL, Muzyczka N, Bessman MJ
Genetics (1973), Volume 73, Page 137
PubMed entry

Polymerases:

T4,T4 A737V,T4 S345P

Topics:

Mutational Analysis, Nucleotide Analogs / Template Lesions, Fidelity, Nucleotide Incorporation

One line summary:

All three of T4 wildtype, T4 tsL141 (A737V, antimutator) and T4 tsL98 (S345P, mutator) DNA polymerases discriminate between adenine and 2-aminopurine, but antimutator (tsL141) incorporates the least of it into DNA.

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