The DNA-polymerase-X family: controllers of DNA quality?

Ramadan K, Shevelev IV, Hübscher U
Nat Rev Mol Cell Biol (2004), Volume 5, Page 1038
PubMed entry Publisher's site

Abstract:

Synthesis of the genetic material of the cell is achieved by a large ...
Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.

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