Steric constraints dependent on nucleobase pair orientation vary in different DNA polymerase active sites.

Streckenbach F, Rangam G, Möller HM, Marx A
Chembiochem (2009), Volume 10, Page 1630
PubMed entry Publisher's site

Abstract:

Finding the right fit: Herein, we report on the development of novel ...
Finding the right fit: Herein, we report on the development of novel steric probes and present initial insights into their interplay with DNA polymerases. Our findings provide experimental evidence for varied enzyme-substrate interactions that might account for the varied selectivity previously observed.

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