Effect of mitoxantrone on DNA polymerase of Ehrlich ascites carcinoma cells.

Xian LJ, Li HX, Liu ZC, Pan QC
Zhongguo Yao Li Xue Bao (1998), Volume 19, Page 356
PubMed entry

Abstract:

AIM: To study the effect of mitoxantrone (Mit) on DNA polymerases of ...
AIM: To study the effect of mitoxantrone (Mit) on DNA polymerases of tumor cells. METHODS: DNA polymerases of Ehrlich ascites carcinoma cells were isolated by phosphocellulose column chromatography. The effects of Mit on DNA polymerase alpha, beta, and gamma were detected by method of K Ono. RESULTS: Mit inhibited DNA polymerase alpha, beta, and gamma, IC50 values were 11.9, 6.5, and 11.9 mumol.L-1, and Ki 1.86, 2.22, and 2.05 mumol.L-1, respectively. The inhibitory mode of Mit on DNA polymerase alpha, beta, and gamma was competitive. CONCLUSION: Mit is a strong inhibitor on DNA polymerase alpha, beta, and gamma. The inhibitory mode was competition with respect to template DNA.

Polymerases:

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