The influence of neighboring base pairs upon base-pair substitution mutation rates.

Koch RE
Proceedings of the National Academy of Sciences of the United States of America (1971), Volume 68, Page 773
PubMed entry Full article text

Abstract:

The 2-aminopurine-induced transition, A.T --> G.C, was studied at ...
The 2-aminopurine-induced transition, A.T --> G.C, was studied at particular sites in bacteriophage T4 as a function of the nearby base-pair composition of the DNA. Changing a base pair changed the transition rate at the adjacent base pair up to 23-fold, and at the next base pair by a lesser amount. Destabilization was achieved by replacing an A.T base pair by a G.C base pair.

Polymerases:

T4

Topics:

Mutational Analysis, Nucleotide Analogs / Template Lesions, Fidelity

Status:

new topics/pols set partial results complete validated

Results:

No results available for this paper.
Log in to add missing results...

Entry validated by:

Log in to validate this paper...

Version:20241007

Using Polbase tables:

Sorting:

Tables may be sorted by clicking on any of the column titles. A second click reverses the sort order. <Ctrl> + click on the column titles to sort by more than one column (e.g. family then name).

Filtering:

It is also possible to filter the table by typing into the search box above the table. This will instantly hide lines from the table that do not contain your search text.