Hydrogen bonding revisited: geometric selection as a principal determinant of DNA replication fidelity.

Goodman MF
Proceedings of the National Academy of Sciences of the United States of America (1997), Volume 94, Page 10493
PubMed entry Full article text

Polymerases:

T4

Topics:

Nucleotide Analogs / Template Lesions, Fidelity, Nucleotide Incorporation, Exonuclease Activity

One line summary:

Hydrogen bonding is not completely essential in the formation of base pairs, difluorotoulene proves this case as a non H-bonding structural facsimile of thymine

Status:

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