HIV-1 subtype C viruses rapidly develop K65R resistance to tenofovir in cell culture.

Brenner BG, Oliveira M, Doualla-Bell F, Moisi DD, Ntemgwa ML, Frankel FA, Essex M, Wainberg MA
AIDS (London, England) (2006), Volume 20, Page F9
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Abstract:

Genotypic diversity among HIV-1 subtypes and circulating recombinant ...
Genotypic diversity among HIV-1 subtypes and circulating recombinant forms (CRF) may lead to distinct pathways to drug resistance. This study evaluated subtype-related differences in the development of resistance in culture to tenofovir.

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