Antiviral activity and resistance profile of phosphazid--a novel prodrug of AZT.

Machado J, Salomon H, Oliveira M, Tsoukas C, Krayevsky AA, Wainberg MA
Nucleosides & nucleotides (), Volume 18, Page 901
PubMed entry

Abstract:

Both AZT and its novel 5'-hydrogen phosphonate derivative, Phosphazid, ...
Both AZT and its novel 5'-hydrogen phosphonate derivative, Phosphazid, possess similar in vitro activity and resistance profiles. Experiments involving AZT-resistant virus isolates revealed a strong correlation between resistance to AZT and cross-resistance to Phosphazid. In vitro selection for resistance to Phosphazid yielded viruses that were about 15-fold less sensitive than wild-type virus to this drug. Sequencing of the reverse transcriptase region of seven Phosphazid-selected viruses revealed a single codon mutation, D67N, that is associated with resistance to AZT.

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