Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.

Maruyama T, Demizu Y, Kozai S, Witvrouw M, Pannecouque C, Balzarini J, Snoecks R, Andrei G, De Clercq E
Nucleosides, nucleotides & nucleic acids (2007), Volume 26, Page 1553
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Abstract:

Antiviral activity of 1,3-disubstituted uracil derivatives was ...
Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV. It appears that the nitrogen of the 1-cyanomethyl group is important for anti-HIV-1 activity, suggesting interaction with the amino acid residues of HIV-1 reverse transcriptase. 1-Arylmethyl derivatives also exhibited good anti-HIV-1 activity; and that of the 2- and 4-picolyl derivatives was particularly excellent.

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HIV RT

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