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Johnson KA

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Publications:

Title Authors Year Journal
Role of induced fit in limiting discrimination against AZT by HIV reverse transcriptase. Johnson KA 2011 Biochemistry
Effect of the Y955C mutation on mitochondrial DNA polymerase nucleotide incorporation efficiency and fidelity. Johnson KA 2011 Biochemistry
Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity. Johnson KA 2011 The Journal of biological chemistry
Role of a GAG hinge in the nucleotide-induced conformational change governing nucleotide specificity by T7 DNA polymerase. Johnson KA 2011 The Journal of biological chemistry
Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity. Johnson KA 2010 The Journal of biological chemistry
Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase. Johnson KA 2010 Proceedings of the National Academy of Sciences of the United States of America
Role of histidine 932 of the human mitochondrial DNA polymerase in nucleotide discrimination and inherited disease. Johnson KA 2010 The Journal of biological chemistry
A single mutation in human mitochondrial DNA polymerase Pol gammaA affects both polymerization and proofreading activities of only the holoenzyme. Johnson KA 2010 The Journal of biological chemistry
The kinetic and chemical mechanism of high-fidelity DNA polymerases. Johnson KA 2010 Biochimica et biophysica acta
High-cell density shake-flask expression and rapid purification of the large fragment of Thermus aquaticus DNA polymerase I using a new chemically and temperature inducible expression plasmid in Escherichia coli. Johnson KA 2009 Protein expression and purification
Site-specific labeling of T7 DNA polymerase with a conformationally sensitive fluorophore and its use in detecting single-nucleotide polymorphisms. Johnson KA 2009 Analytical biochemistry
Kinetic investigation of the inhibitory effect of gemcitabine on DNA polymerization catalyzed by human mitochondrial DNA polymerase. Johnson KA 2008 The Journal of biological chemistry
Exonuclease removal of dideoxycytidine (zalcitabine) by the human mitochondrial DNA polymerase. Johnson KA 2008 Antimicrobial agents and chemotherapy
Base pair hydrogen bonds are essential for proofreading selectivity by the human mitochondrial DNA polymerase. Johnson KA 2008 The Journal of biological chemistry
Importance of hydrogen bonding for efficiency and specificity of the human mitochondrial DNA polymerase. Johnson KA 2008 The Journal of biological chemistry
Structure of the DNA repair helicase hel308 reveals DNA binding and autoinhibitory domains. Johnson KA 2008 The Journal of biological chemistry
Role of induced fit in enzyme specificity: a molecular forward/reverse switch. Johnson KA 2008 The Journal of biological chemistry
A novel mechanism of selectivity against AZT by the human mitochondrial DNA polymerase. Johnson KA 2007 Nucleic acids research
Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity. Johnson KA 2007 The Journal of biological chemistry
Fidelity and processivity of reverse transcription by the human mitochondrial DNA polymerase. Johnson KA 2007 The Journal of biological chemistry
Fidelity of the human mitochondrial DNA polymerase. Johnson KA 2006 The Journal of biological chemistry
A new paradigm for DNA polymerase specificity. Johnson KA 2006 Biochemistry
Incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial DNA polymerase. Johnson KA 2006 The Journal of biological chemistry
Analysis of single nucleotide incorporation reactions by capillary electrophoresis. Johnson KA 2005 Analytical biochemistry
Novel mechanism of inhibition of HIV-1 reverse transcriptase by a new non-nucleoside analog, KM-1. Johnson KA 2004 The Journal of biological chemistry
Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase. Johnson KA 2004 Antimicrobial agents and chemotherapy
Insights into DNA replication: the crystal structure of DNA polymerase B1 from the archaeon Sulfolobus solfataricus. Johnson KA 2004 Structure (London, England : 1993)
Characterization of novel reverse transcriptase and other RNA-associated catalytic activities by human DNA polymerase gamma: importance in mitochondrial DNA replication. Johnson KA 2003 The Journal of biological chemistry
Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase. Johnson KA 2003 Biochemistry
Fidelity of nucleotide incorporation by human mitochondrial DNA polymerase. Johnson KA 2001 The Journal of biological chemistry
Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase. Johnson KA 2001 The Journal of biological chemistry
Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs. Johnson KA 2001 The Journal of biological chemistry
Exonuclease proofreading by human mitochondrial DNA polymerase. Johnson KA 2001 The Journal of biological chemistry
Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization. Johnson KA 2000 Biochemistry
Single d(GpG)/cis-diammineplatinum(II) adduct-induced inhibition of DNA polymerization. Johnson KA 1999 Biochemistry
DNA secondary structure effects on DNA synthesis catalyzed by HIV-1 reverse transcriptase. Johnson KA 1998 The Journal of biological chemistry
Expression, purification, and initial kinetic characterization of the large subunit of the human mitochondrial DNA polymerase. Johnson KA 1998 Biochemistry
Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine. Johnson KA 1998 The Journal of biological chemistry
RNA secondary structure switching during DNA synthesis catalyzed by HIV-1 reverse transcriptase. Johnson KA 1997 Biochemistry
Effect of RNA secondary structure on RNA cleavage catalyzed by HIV-1 reverse transcriptase. Johnson KA 1997 Biochemistry
Effect of RNA secondary structure on the kinetics of DNA synthesis catalyzed by HIV-1 reverse transcriptase. Johnson KA 1997 Biochemistry
Slow rate of phosphodiester bond formation accounts for the strong bias that Taq DNA polymerase shows against 2',3'-dideoxynucleotide terminators. Johnson KA 1996 Biochemistry
HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors. Johnson KA 1996 Biochemistry
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Johnson KA 1995 Science
Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates. Johnson KA 1995 Methods in enzymology
Mutants affecting nucleotide recognition by T7 DNA polymerase. Johnson KA 1994 Biochemistry
Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit. Johnson KA 1994 Proceedings of the National Academy of Sciences of the United States of America
Conformational coupling in DNA polymerase fidelity. Johnson KA 1993 Annual review of biochemistry
Conformational coupling in DNA polymerase information transfer. Johnson KA 1992 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Mechanism and fidelity of HIV reverse transcriptase. Johnson KA 1992 The Journal of biological chemistry
Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant. Johnson KA 1991 Biochemistry
Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction. Johnson KA 1991 Biochemistry
An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics. Johnson KA 1991 Biochemistry
Kinetic mechanism of DNA polymerase I (Klenow). Johnson KA 1987 Biochemistry
Rate-limiting steps in the DNA polymerase I reaction pathway. Johnson KA 1985 Biochemistry
Continuous assay for DNA polymerization by light scattering. Johnson KA 1984 Analytical biochemistry
Elementary steps in the DNA polymerase I reaction pathway. Johnson KA 1983 Biochemistry

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