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Woodgate R

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Publications:

Title Authors Year Journal
Removal of misincorporated ribonucleotides from prokaryotic genomes: an unexpected role for nucleotide excision repair. Woodgate R 2013 PLoS genetics
A short adaptive path from DNA to RNA polymerases. Woodgate R 2012 Proceedings of the National Academy of Sciences of the United States of America
Critical amino acids in Escherichia coli UmuC responsible for sugar discrimination and base-substitution fidelity. Woodgate R 2012 Nucleic acids research
Mechanisms Employed by Escherichia coli to Prevent Ribonucleotide Incorporation into Genomic DNA by Pol V. Woodgate R 2012 PLoS genetics
Escherichia coli UmuC active site mutants: Effects on translesion DNA synthesis, mutagenesis and cell survival. Woodgate R 2012 DNA repair
Simple and efficient purification of Escherichia coli DNA polymerase V: Cofactor requirements for optimal activity and processivity in vitro. Woodgate R 2012 DNA repair
A new model for SOS-induced mutagenesis: how RecA protein activates DNA polymerase V. Woodgate R 2010 Crit Rev Biochem Mol Biol
The active form of DNA polymerase V is UmuD'(2)C-RecA-ATP. Woodgate R 2009 Nature
DNA polymerase switching: effects on spontaneous mutagenesis in Escherichia coli. Woodgate R 2009 Molecular microbiology
Insights into the cellular role of enigmatic DNA polymerase iota. Woodgate R 2009 DNA repair
Construction of a circular single-stranded DNA template containing a defined lesion. Woodgate R 2009 DNA repair
A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Woodgate R 2009 Nucleic acids research
Xeroderma pigmentosum-variant patients from America, Europe, and Asia. Woodgate R 2008 The Journal of investigative dermatology
What a difference a decade makes: insights into translesion DNA synthesis. Woodgate R 2007 Proceedings of the National Academy of Sciences of the United States of America
Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese. Woodgate R 2007 The Journal of biological chemistry
Molecular breeding of polymerases for amplification of ancient DNA. Woodgate R 2007 Nature biotechnology
Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations. Woodgate R 2007 Cancer research
Purification and characterization of Escherichia coli DNA polymerase V. Woodgate R 2006 Methods in enzymology
Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota. Woodgate R 2006 DNA repair
Novel thermostable Y-family polymerases: applications for the PCR amplification of damaged or ancient DNAs. Woodgate R 2006 Nucleic acids research
DNA polymerase iota-dependent translesion replication of uracil containing cyclobutane pyrimidine dimers. Woodgate R 2006 DNA repair
RecA acts in trans to allow replication of damaged DNA by DNA polymerase V. Woodgate R 2006 Nature
The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimer. Woodgate R 2005 Genetics
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. Woodgate R 2005 J Exp Med
DNA polymerase V and RecA protein, a minimal mutasome. Woodgate R 2005 Molecular cell
Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination. Woodgate R 2005 Molecular cell
Lyase activities intrinsic to Escherichia coli polymerases IV and V. Woodgate R 2005 DNA repair
Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. Woodgate R 2005 The EMBO journal
Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases. Woodgate R 2004 Curr Opin Genet Dev
Investigating the role of the little finger domain of Y-family DNA polymerases in low fidelity synthesis and translesion replication. Woodgate R 2004 The Journal of biological chemistry
Snapshots of replication through an abasic lesion; structural basis for base substitutions and frameshifts. Woodgate R 2004 Molecular cell
Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase. Woodgate R 2004 Proceedings of the National Academy of Sciences of the United States of America
Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution. Woodgate R 2004 Nat Biotechnol
Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota. Woodgate R 2004 The Journal of biological chemistry
Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota. Woodgate R 2003 DNA repair
129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. Woodgate R 2003 J Exp Med
Escherichia coli DNA polymerase V subunit exchange: a post-SOS mechanism to curtail error-prone DNA synthesis. Woodgate R 2003 The Journal of biological chemistry
Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. Woodgate R 2003 The Journal of biological chemistry
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. Woodgate R 2003 The EMBO journal
Replication of a cis-syn thymine dimer at atomic resolution. Woodgate R 2003 Nature
Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota. Woodgate R 2002 Nucleic acids research
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. Woodgate R 2002 The EMBO journal
Escherichia coli DNA polymerase III can replicate efficiently past a T-T cis-syn cyclobutane dimer if DNA polymerase V and the 3' to 5' exonuclease proofreading function encoded by dnaQ are inactivated. Woodgate R 2002 Journal of bacteriology
The "tale" of UmuD and its role in SOS mutagenesis. Woodgate R 2002 BioEssays : news and reviews in molecular, cellular and developmental biology
Two distinct modes of RecA action are required for DNA polymerase V-catalyzed translesion synthesis. Woodgate R 2002 Proceedings of the National Academy of Sciences of the United States of America
Low fidelity DNA synthesis by a y family DNA polymerase due to misalignment in the active site. Woodgate R 2002 The Journal of biological chemistry
Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass. Woodgate R 2002 DNA repair
Sequence analysis and phenotypes of five temperature sensitive mutator alleles of dnaE, encoding modified alpha-catalytic subunits of Escherichia coli DNA polymerase III holoenzyme. Woodgate R 2002 Mutation research
Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines. Woodgate R 2001 The EMBO journal
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro. Woodgate R 2001 Science
Biochemical characterization of human DNA polymerase iota provides clues to its biological function. Woodgate R 2001 Biochem Soc Trans
Human DNA polymerase iota promiscuous mismatch extension. Woodgate R 2001 The Journal of biological chemistry
Roles of DNA polymerases V and II in SOS-induced error-prone and error-free repair in Escherichia coli. Woodgate R 2001 Proceedings of the National Academy of Sciences of the United States of America
Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template. Woodgate R 2001 The EMBO journal
Evolution of the two-step model for UV-mutagenesis. Woodgate R 2001 Mutation research
Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta. Woodgate R 2001 Nucleic acids research
DNA polymerase iota and related rad30-like enzymes. Woodgate R 2001 Philosophical transactions of the Royal Society of London. Series B, Biological sciences
A model for SOS-lesion-targeted mutations in Escherichia coli. Woodgate R 2001 Nature
Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication. Woodgate R 2001 Cell
Eukaryotic DNA polymerases: proposal for a revised nomenclature. Woodgate R 2001 The Journal of biological chemistry
The biochemical basis and in vivo regulation of SOS-induced mutagenesis promoted by Escherichia coli DNA polymerase V (UmuD'2C). Woodgate R 2000 Cold Spring Harbor symposia on quantitative biology
Intrinsic polymerase activities of UmuD'(2)C and MucA'(2)B are responsible for their different mutagenic properties during bypass of a T-T cis-syn cyclobutane dimer. Woodgate R 2000 Journal of bacteriology
Subunit-specific degradation of the UmuD/D' heterodimer by the ClpXP protease: the role of trans recognition in UmuD' stability. Woodgate R 2000 The EMBO journal
poliota, a remarkably error-prone human DNA polymerase. Woodgate R 2000 Genes & development
Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota. Woodgate R 2000 The EMBO journal
Visualization of two binding sites for the Escherichia coli UmuD'(2)C complex (DNA pol V) on RecA-ssDNA filaments. Woodgate R 2000 Journal of molecular biology
A phenotype for enigmatic DNA polymerase II: a pivotal role for pol II in replication restart in UV-irradiated Escherichia coli. Woodgate R 1999 Proceedings of the National Academy of Sciences of the United States of America
UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V. Woodgate R 1999 Proceedings of the National Academy of Sciences of the United States of America
Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta. Woodgate R 1999 Genomics
A plethora of lesion-replicating DNA polymerases. Woodgate R 1999 Genes Dev
Efficient translesion replication in the absence of Escherichia coli Umu proteins and 3'-5' exonuclease proofreading function. Woodgate R 1998 Proceedings of the National Academy of Sciences of the United States of America
Unusual insertion element polymorphisms in the promoter and terminator regions of the mucAB-like genes of R471a and R446b. Woodgate R 1998 Mutation research
Enhanced generation of A:T-->T:A transversions in a recA730 lexA51(Def) mutant of Escherichia coli. Woodgate R 1997 Mutation research
Identification of a DinB/UmuC homolog in the archeon Sulfolobus solfataricus. Woodgate R 1996 Mutation research
Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis. Woodgate R 1996 Journal of bacteriology
The UmuD' protein filament and its potential role in damage induced mutagenesis. Woodgate R 1996 Structure (London, England : 1993)
Structure of the UmuD' protein and its regulation in response to DNA damage. Woodgate R 1996 Nature
Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III. Woodgate R 1992 Proceedings of the National Academy of Sciences of the United States of America
Levels of chromosomally encoded Umu proteins and requirements for in vivo UmuD cleavage. Woodgate R 1991 Molecular & general genetics : MGG
UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD'. Woodgate R 1989 Proceedings of the National Academy of Sciences of the United States of America
Current understanding of UV-induced base pair substitution mutation in E. coli with particular reference to the DNA polymerase III complex. Woodgate R 1987 Mutation research
Mutagenic DNA repair in Escherichia coli. XIII. Proofreading exonuclease of DNA polymerase III holoenzyme is not operational during UV mutagenesis. Woodgate R 1987 Mutation research

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