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Wilson SH

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Publications:

Title Authors Year Journal
Human DNA Polymerase-beta Promoter: Phorbol Ester Activation Is Mediated through the cAMP Response Element and cAMP-Response-Element-Binding Protein. Wilson SH Journal of biomedical science
A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways. Wilson SH Molekuliarnaia biologiia
Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break. Wilson SH Molecular immunology
Inhibition of HIV-1 Reverse Transcriptase-Catalyzed Synthesis by Intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide Adducts. Wilson SH 2013 PloS one
Amino acid substitution in the active site of DNA polymerase β explains the energy barrier of the nucleotidyl transfer reaction. Wilson SH 2013 Journal of the American Chemical Society
Insights into the Conformation of Aminofluorene-dG Adduct in a DNA Polymerase Active Site. Wilson SH 2013 The Journal of biological chemistry
Interaction between DNA Polymerase β and BRCA1. Wilson SH 2013 PloS one
Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity. Wilson SH 2013 Frontiers in oncology
Observing a DNA polymerase choose right from wrong. Wilson SH 2013 Cell
Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. Wilson SH 2013 DNA repair
Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer. Wilson SH 2013 International journal of oncology
Pol β associated complex and base excision repair factors in mouse fibroblasts. Wilson SH 2012 Nucleic acids research
β,γ-CHF- and β,γ-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures and absolute configurations of new stereochemical probes for DNA polymerases. Wilson SH 2012 Journal of the American Chemical Society
Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly. Wilson SH 2012 Structure (London, England : 1993)
Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts. Wilson SH 2012 PloS one
DNA Polymerase β Gap-filling Translesion DNA Synthesis. Wilson SH 2012 Chemical research in toxicology
Effect of β,γ-CHF- and β,γ-CHCl-dGTP Halogen Atom Stereochemistry on the Transition State of DNA Polymerase β Wilson SH 2012 Biochemistry
Evidence for Abasic Site Sugar Phosphate-Mediated Cytotoxicity in Alkylating Agent Treated Saccharomyces cerevisiae. Wilson SH 2012 PloS one
DNA base excision repair: a mechanism of trinucleotide repeat expansion. Wilson SH 2012 Trends in biochemical sciences
DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion. Wilson SH 2012 Nucleic acids research
Perspective: pre-chemistry conformational changes in DNA polymerase mechanisms. Wilson SH 2012 Theoretical chemistry accounts
Molecular insights into DNA polymerase deterrents for ribonucleotide insertion. Wilson SH 2011 The Journal of biological chemistry
Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase {beta} Wilson SH 2011 Nucleic acids research
Metal-induced DNA translocation leads to DNA polymerase conformational activation. Wilson SH 2011 Nucleic acids research
Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion. Wilson SH 2011 Proceedings of the National Academy of Sciences of the United States of America
DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts. Wilson SH 2010 PloS one
Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues. Wilson SH 2010 Journal of the American Chemical Society
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Wilson SH 2010 Proceedings of the National Academy of Sciences of the United States of America
Base excision repair and design of small molecule inhibitors of human DNA polymerase beta. Wilson SH 2010 Cell Mol Life Sci
Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Wilson SH 2010 Nature structural & molecular biology
DNA polymerase beta ribonucleotide discrimination: insertion, misinsertion, extension, and coding. Wilson SH 2010 The Journal of biological chemistry
DNA polymerase beta-dependent long patch base excision repair in living cells. Wilson SH 2010 DNA repair
DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine. Wilson SH 2010 Mutation research
Substrate channeling in mammalian base excision repair pathways: passing the baton. Wilson SH 2010 The Journal of biological chemistry
DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". Wilson SH 2009 The Journal of biological chemistry
DNA polymerase beta and PARP activities in base excision repair in living cells. Wilson SH 2009 DNA repair
Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Wilson SH 2009 Org Lett
Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Wilson SH 2009 Nucleic acids research
A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Wilson SH 2009 Nucleic acids research
Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA. Wilson SH 2009 Mutation research
Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. Wilson SH 2009 PloS one
XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Wilson SH 2008 Cell research
Exploring the role of large conformational changes in the fidelity of DNA polymerase beta. Wilson SH 2008 Proteins
Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice. Wilson SH 2008 Biol Reprod
Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Wilson SH 2008 Molecular cell
DNA polymerase beta fidelity: halomethylene-modified leaving groups in pre-steady-state kinetic analysis reveal differences at the chemical transition state. Wilson SH 2008 Biochemistry
Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta. Wilson SH 2008 Proceedings of the National Academy of Sciences of the United States of America
Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT. Wilson SH 2008 J Med Chem
HMGB1 is a cofactor in mammalian base excision repair. Wilson SH 2007 Molecular cell
Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. Wilson SH 2007 The Journal of biological chemistry
Different structural states in oligonucleosomes are required for early versus late steps of base excision repair. Wilson SH 2007 Nucleic acids research
Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. Wilson SH 2007 DNA repair
Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency. Wilson SH 2007 DNA repair
Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines. Wilson SH 2007 DNA repair
Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: improved accuracy in studies of structural features and mutational effects. Wilson SH 2007 Journal of molecular biology
Differing conformational pathways before and after chemistry for insertion of dATP versus dCTP opposite 8-oxoG in DNA polymerase beta. Wilson SH 2007 Biophys J
Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta. Wilson SH 2007 The Journal of biological chemistry
Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. Wilson SH 2007 Biochemistry
The X family portrait: structural insights into biological functions of X family polymerases. Wilson SH 2007 DNA repair
(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Wilson SH 2007 Journal of the American Chemical Society
Activities and mechanism of DNA polymerase beta. Wilson SH 2006 Methods in enzymology
Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Wilson SH 2006 Structure (London, England : 1993)
Energy analysis of chemistry for correct insertion by DNA polymerase beta. Wilson SH 2006 Proceedings of the National Academy of Sciences of the United States of America
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Wilson SH 2006 Proceedings of the National Academy of Sciences of the United States of America
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. Wilson SH 2006 Cancer research
Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection. Wilson SH 2006 Biochemistry
Determination of lysine pK values using [5-13C]lysine: application to the lyase domain of DNA Pol beta. Wilson SH 2006 Journal of the American Chemical Society
Structure and mechanism of DNA polymerase Beta. Wilson SH 2006 Chem Rev
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Wilson SH 2006 Molecular cell
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. Wilson SH 2006 DNA repair
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Wilson SH 2006 Nucleic acids research
DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. Wilson SH 2005 The Journal of biological chemistry
Syn-full behavior by T7 DNA polymerase. Wilson SH 2005 Structure (London, England : 1993)
Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity. Wilson SH 2005 Nucleic acids research
Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Wilson SH 2005 Structure (London, England : 1993)
Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism. Wilson SH 2005 DNA repair
REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast. Wilson SH 2005 DNA repair
Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure. Wilson SH 2005 The Journal of biological chemistry
Base excision repair in nucleosomes lacking histone tails. Wilson SH 2005 DNA repair
A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase beta ternary complex. Wilson SH 2005 Biochemistry
Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death. Wilson SH 2005 DNA repair
DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair. Wilson SH 2005 The Journal of biological chemistry
DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts. Wilson SH 2005 The Journal of biological chemistry
Mismatch-induced conformational distortions in polymerase beta support an induced-fit mechanism for fidelity. Wilson SH 2005 Biochemistry
Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates. Wilson SH 2004 The Journal of biological chemistry
AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate. Wilson SH 2004 DNA repair
AP endonuclease-independent DNA base excision repair in human cells. Wilson SH 2004 Molecular cell
Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly. Wilson SH 2004 Journal of the American Chemical Society
In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Wilson SH 2004 Proceedings of the National Academy of Sciences of the United States of America
Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity. Wilson SH 2004 Structure (London, England : 1993)
High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase. Wilson SH 2004 Protein expression and purification
Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses. Wilson SH 2004 Biophys J
Dynamic characterization of a DNA repair enzyme: NMR studies of [methyl-13C]methionine-labeled DNA polymerase beta. Wilson SH 2004 Biochemistry
Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping. Wilson SH 2004 The Journal of biological chemistry
Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes. Wilson SH 2003 Proceedings of the National Academy of Sciences of the United States of America
Rapid segmental and subdomain motions of DNA polymerase beta. Wilson SH 2003 The Journal of biological chemistry
DNA polymerase beta gene expression: the promoter activator CREB-1 is upregulated in Chinese hamster ovary cells by DNA alkylating agent-induced stress. Wilson SH 2003 Biological chemistry
Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions. Wilson SH 2003 DNA repair
Structural insights into the origins of DNA polymerase fidelity. Wilson SH 2003 Structure (London, England : 1993)
Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential. Wilson SH 2003 Structure (London, England : 1993)
Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice. Wilson SH 2003 DNA repair
The base substitution fidelity of DNA polymerase beta-dependent single nucleotide base excision repair. Wilson SH 2003 The Journal of biological chemistry
Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. Wilson SH 2003 The Journal of biological chemistry
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. Wilson SH 2003 The Journal of biological chemistry
Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens. Wilson SH 2003 Cancer research
Cloning and characterization of a novel member of the human ATF/CREB family: ATF2 deletion, a potential regulator of the human DNA polymerase beta promoter. Wilson SH 2003 Gene
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. Wilson SH 2003 The Journal of biological chemistry
Polymerase beta simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se. Wilson SH 2002 Journal of molecular biology
Binary system for selective photoaffinity labeling of base excision repair DNA polymerases. Wilson SH 2002 Nucleic acids research
Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. Wilson SH 2002 The Journal of biological chemistry
DNA polymerase beta. Wilson SH 2002 Int J Biochem Cell Biol
Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage. Wilson SH 2002 DNA repair
Mapping of the interaction interface of DNA polymerase beta with XRCC1. Wilson SH 2002 Structure (London, England : 1993)
Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen. Wilson SH 2002 The Journal of biological chemistry
1H, 13C and 15N resonance assignments for the perdeuterated 22 kD palm-thumb domain of DNA polymerase beta. Wilson SH 2002 J Biomol NMR
Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. Wilson SH 2002 The Journal of biological chemistry
Local deformations revealed by dynamics simulations of DNA polymerase Beta with DNA mismatches at the primer terminus. Wilson SH 2002 Journal of molecular biology
DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis. Wilson SH 2001 The Journal of biological chemistry
A role for p53 in base excision repair. Wilson SH 2001 The EMBO journal
DNA lesion bypass polymerases open up. Wilson SH 2001 Structure (London, England : 1993)
The HIV-1 transactivator protein Tat is a potent inducer of the human DNA repair enzyme beta-polymerase. Wilson SH 2001 AIDS (London, England)
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro. Wilson SH 2001 Science
A type IB topoisomerase with DNA repair activities. Wilson SH 2001 Proceedings of the National Academy of Sciences of the United States of America
DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta. Implication for the identity of the rate-limiting conformational change. Wilson SH 2001 The Journal of biological chemistry
DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts. Wilson SH 2001 Biochemistry
Relationship between base excision repair capacity and DNA alkylating agent sensitivity in mouse monocytes. Wilson SH 2001 Mutation research
Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair. Wilson SH 2001 The Journal of biological chemistry
Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair. Wilson SH 2000 The Journal of biological chemistry
8-oxodGTP incorporation by DNA polymerase beta is modified by active-site residue Asn279. Wilson SH 2000 Biochemistry
FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair. Wilson SH 2000 The Journal of biological chemistry
Domain specific interaction in the XRCC1-DNA polymerase beta complex. Wilson SH 2000 Nucleic acids research
Mapping of the 5'-2-deoxyribose-5-phosphate lyase active site in DNA polymerase beta by mass spectrometry. Wilson SH 2000 The Journal of biological chemistry
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta. Wilson SH 2000 Mutation research
Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity. Wilson SH 2000 Journal of molecular biology
DNA polymerase beta and mammalian base excision repair. Wilson SH 2000 Cold Spring Harbor symposia on quantitative biology
Vertical-scanning mutagenesis of a critical tryptophan in the "minor groove binding track" of HIV-1 reverse transcriptase. Major groove DNA adducts identify specific protein interactions in the minor groove. Wilson SH 2000 The Journal of biological chemistry
Kinetic analysis of Sp1-mediated transcriptional activation of the human DNA polymerase beta promoter. Wilson SH 2000 Oncogene
Minor groove interactions at the DNA polymerase beta active site modulate single-base deletion error rates. Wilson SH 2000 The Journal of biological chemistry
Modulation of base excision repair by low density lipoprotein, oxidized low density lipoprotein and antioxidants in mouse monocytes. Wilson SH 2000 Carcinogenesis
Kinetic analysis of Sp1-mediated transcriptional activation of a TATA-containing promoter. Wilson SH 2000 Biochemistry
Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair. Wilson SH 1999 The Journal of biological chemistry
Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer. Wilson SH 1999 The Journal of biological chemistry
Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage. Wilson SH 1999 Cancer research
"Action-at-a-distance" mutagenesis. 8-oxo-7, 8-dihydro-2'-deoxyguanosine causes base substitution errors at neighboring template sites when copied by DNA polymerase beta. Wilson SH 1999 The Journal of biological chemistry
DNA polymerase beta expression differences in selected human tumors and cell lines. Wilson SH 1999 Carcinogenesis
The fidelity of DNA polymerase beta during distributive and processive DNA synthesis. Wilson SH 1999 The Journal of biological chemistry
Base substitution specificity of DNA polymerase beta depends on interactions in the DNA minor groove. Wilson SH 1999 The Journal of biological chemistry
HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system. Wilson SH 1999 The international journal of biochemistry & cell biology
Uniquely altered DNA replication fidelity conferred by an amino acid change in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase. Wilson SH 1999 The Journal of biological chemistry
Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta. Wilson SH 1998 The Journal of biological chemistry
Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells. Wilson SH 1998 Biochemistry
Subunits of human replication protein A are crosslinked by photoreactive primers synthesized by DNA polymerases. Wilson SH 1998 Nucleic acids research
Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro. Wilson SH 1998 Proceedings of the National Academy of Sciences of the United States of America
Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA. Wilson SH 1998 The Journal of biological chemistry
Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions. Wilson SH 1998 The Journal of biological chemistry
Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities. Wilson SH 1998 The Journal of biological chemistry
Interactions between DNA polymerase beta and the major covalent adduct of the carcinogen (+)-anti-benzo[a]pyrene diol epoxide with DNA at a primer-template junction. Wilson SH 1998 Biochemistry
Mammalian base excision repair by DNA polymerases delta and epsilon. Wilson SH 1998 Oncogene
Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps. Wilson SH 1998 The Journal of biological chemistry
Mammalian base excision repair and DNA polymerase beta. Wilson SH 1998 Mutation research
Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines. Wilson SH 1998 Nucleic acids research
Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism. Wilson SH 1998 The Journal of biological chemistry
Structural insights into DNA polymerase beta fidelity: hold tight if you want it right. Wilson SH 1998 Chemistry & biology
Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-guanine adducts. Wilson SH 1997 The Journal of biological chemistry
Abasic translesion synthesis by DNA polymerase beta violates the "A-rule". Novel types of nucleotide incorporation by human DNA polymerase beta at an abasic lesion in different sequence contexts. Wilson SH 1997 The Journal of biological chemistry
DNA polymerase beta in abasic site repair: a structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes. Wilson SH 1997 Biochemistry
Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Wilson SH 1997 Biochemistry
A minor groove binding track in reverse transcriptase. Wilson SH 1997 Nat Struct Biol
Replication of O6-methylguanine-containing DNA by repair and replicative DNA polymerases. Wilson SH 1996 The Journal of biological chemistry
Role of the "helix clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis. Wilson SH 1996 The Journal of biological chemistry
Three-dimensional solution structure of the N-terminal domain of DNA polymerase beta and mapping of the ssDNA interaction interface. Wilson SH 1996 Biochemistry
A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta. Wilson SH 1996 Biochemistry
Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta. Wilson SH 1996 The Journal of biological chemistry
Requirement of mammalian DNA polymerase-beta in base-excision repair. Wilson SH 1996 Nature
dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase beta as revealed by affinity labeling with a photoreactive dNTP analog. Wilson SH 1996 The Journal of biological chemistry
dNTP binding site in rat DNA polymerase beta revealed by controlled proteolysis and azido photoprobe cross-linking. Wilson SH 1996 Biochemistry
Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis. Wilson SH 1996 The Journal of biological chemistry
Evidence for an imino intermediate in the DNA polymerase beta deoxyribose phosphate excision reaction. Wilson SH 1996 The Journal of biological chemistry
Identification of novel mRNA isoforms for human DNA polymerase beta. Wilson SH 1996 DNA Cell Biol
Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity. Wilson SH 1996 Biochemistry
Purification and characterization of a DNA polymerase beta promoter initiator element-binding transcription factor from bovine testis. Wilson SH 1996 Biochemistry
DNA polymerases alpha and beta are required for DNA repair in an efficient nuclear extract from Xenopus oocytes. Wilson SH 1996 The Journal of biological chemistry
Activation of the human DNA polymerase beta promoter by a DNA-alkylating agent through induced phosphorylation of cAMP response element-binding protein-1. Wilson SH 1996 The Journal of biological chemistry
The bovine DNA polymerase beta promoter: cloning, characterization and comparison with the human core promoter. Wilson SH 1995 Gene
DNA polymerase beta conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. Wilson SH 1995 The Journal of biological chemistry
Specific inhibition of DNA polymerase beta by its 14 kDa domain: role of single- and double-stranded DNA binding and 5'-phosphate recognition. Wilson SH 1995 Nucleic acids research
Phorbol ester abrogates up-regulation of DNA polymerase beta by DNA-alkylating agents in Chinese hamster ovary cells. Wilson SH 1995 The Journal of biological chemistry
DNA damage-induced transcriptional activation of a human DNA polymerase beta chimeric promoter: recruitment of preinitiation complex in vitro by ATF/CREB. Wilson SH 1995 Biochemistry
Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain. Wilson SH 1995 The Journal of biological chemistry
Strategic down-regulation of DNA polymerase beta by antisense RNA sensitizes mammalian cells to specific DNA damaging agents. Wilson SH 1995 Nucleic acids research
Purification and domain-mapping of mammalian DNA polymerase beta. Wilson SH 1995 Methods in enzymology
Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. Wilson SH 1995 The Journal of biological chemistry
Site-directed mutagenesis of HIV reverse transcriptase to probe enzyme processivity and drug binding. Wilson SH 1994 Current opinion in biotechnology
Characterization of the tryptophan fluorescence and hydrodynamic properties of rat DNA polymerase beta. Wilson SH 1994 Journal of molecular biology
Assignments of 1H, 15N, and 13C resonances for the backbone and side chains of the N-terminal domain of DNA polymerase beta. Determination of the secondary structure and tertiary contacts. Wilson SH 1994 Biochemistry
Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism. Wilson SH 1994 Science
Studies of gapped DNA substrate binding by mammalian DNA polymerase beta. Dependence on 5'-phosphate group. Wilson SH 1994 The Journal of biological chemistry
Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP. Wilson SH 1994 Science
The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression. Wilson SH 1994 Nucleic acids research
Studies on primer binding of HIV-1 reverse transcriptase using a fluorescent probe. Wilson SH 1994 Journal of molecular biology
Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase. Alanine scanning mutagenesis of an alpha-helix in the thumb subdomain. Wilson SH 1994 The Journal of biological chemistry
Mapping of nucleic acid binding in proteolytic domains of HIV-1 reverse transcriptase. Wilson SH 1993 Biochemistry
Expression of polypeptides of human immunodeficiency virus-1 reverse transcriptase in Escherichia coli. Wilson SH 1993 Protein expression and purification
Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots. Wilson SH 1993 The Journal of biological chemistry
HIV-1 reverse transcriptase: inhibition by 2',5'-oligoadenylates. Wilson SH 1993 Biochemistry
Short gap-filling synthesis by DNA polymerase beta is processive. Wilson SH 1993 The Journal of biological chemistry
Yeast open reading frame YCR14C encodes a DNA beta-polymerase-like enzyme. Wilson SH 1993 Nucleic acids research
Kinetic analysis of template.primer interactions with recombinant forms of HIV-1 reverse transcriptase. Wilson SH 1993 Biochemistry
Mechanism of HIV-1 reverse transcriptase. Termination of processive synthesis on a natural DNA template is influenced by the sequence of the template-primer stem. Wilson SH 1993 The Journal of biological chemistry
Identification of residues in the single-stranded DNA-binding site of the 8-kDa domain of rat DNA polymerase beta by UV cross-linking. Wilson SH 1993 The Journal of biological chemistry
Expression and purification of the HIV-1 reverse transcriptase using the baculovirus expression vector system. Wilson SH 1993 Protein expression and purification
Inhibitors of HIV-1 reverse transcriptase and fidelity of in vitro DNA replication. Wilson SH 1992 Journal of enzyme inhibition
Mammalian DNA polymerase beta: characterization of a 16-kDa transdomain fragment containing the nucleic acid-binding activities of the native enzyme. Wilson SH 1992 Biochemistry
DNA polymerase beta and DNA synthesis in Xenopus oocytes and in a nuclear extract. Wilson SH 1992 Science
Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: implications for primer binding. Wilson SH 1991 Biochemistry
A leucine zipper-like motif may mediate HIV reverse transcriptase subunit binding. Wilson SH 1991 The New biologist
Thermodynamics of A:G mismatch poly(dG) synthesis by human immunodeficiency virus 1 reverse transcriptase. Wilson SH 1991 The Journal of biological chemistry
The ATF/CREB transcription factor-binding site in the polymerase beta promoter mediates the positive effect of N-methyl-N'-nitro-N-nitrosoguanidine on transcription. Wilson SH 1991 Proceedings of the National Academy of Sciences of the United States of America
Mammalian beta-polymerase promoter: phosphorylation of ATF/CRE-binding protein and regulation of DNA binding. Wilson SH 1991 Nucleic acids research
Protein-protein interactions of HIV-1 reverse transcriptase: implication of central and C-terminal regions in subunit binding. Wilson SH 1991 Biochemistry
Identification and properties of the catalytic domain of mammalian DNA polymerase beta. Wilson SH 1990 Biochemistry
Protein binding elements in the human beta-polymerase promoter. Wilson SH 1990 Nucleic acids research
Mapping of the gene for DNA polymerase beta to mouse chromosome 8. Wilson SH 1990 Cytogenetics and cell genetics
Transfected human beta-polymerase promoter contains a ras-responsive element. Wilson SH 1990 Molecular and cellular biology
Purification and characterization of the RNase H domain of HIV-1 reverse transcriptase expressed in recombinant Escherichia coli. Wilson SH 1990 FEBS letters
Mechanism of HIV reverse transcriptase: enzyme-primer interaction as revealed through studies of a dNTP analogue, 3'-azido-dTTP. Wilson SH 1990 Biochemistry
Deregulation of DNA polymerase beta by sense and antisense RNA expression in mouse 3T3 cells alters cell growth. Wilson SH 1990 Somatic cell and molecular genetics
Studies of the domain structure of mammalian DNA polymerase beta. Identification of a discrete template binding domain. Wilson SH 1990 The Journal of biological chemistry
Levels and size complexity of DNA polymerase beta mRNA in rat regenerating liver and other organs. Wilson SH 1989 Biochimica et biophysica acta
Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide. Wilson SH 1989 Biochemistry
Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase. Wilson SH 1989 The Journal of biological chemistry
Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells. Wilson SH 1989 Molecular and cellular biology
Active-site modification of mammalian DNA polymerase beta with pyridoxal 5'-phosphate: mechanism of inhibition and identification of lysine 71 in the deoxynucleoside triphosphate binding pocket. Wilson SH 1989 Biochemistry
Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter. Wilson SH 1988 The Journal of biological chemistry
Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme. Wilson SH 1988 Biochemistry
Characterization of DNA polymerase beta mRNA: cell-cycle and growth response in cultured human cells. Wilson SH 1988 Nucleic acids research
Studies on the mechanism of Escherichia coli DNA polymerase I large fragment. Effect of template sequence and substrate variation on termination of synthesis. Wilson SH 1988 The Journal of biological chemistry
Studies on the mechanism of human immunodeficiency virus reverse transcriptase. Steady-state kinetics, processivity, and polynucleotide inhibition. Wilson SH 1988 The Journal of biological chemistry
Chromosomal location of the human gene for DNA polymerase beta. Wilson SH 1987 Proceedings of the National Academy of Sciences of the United States of America
Genetic relatedness of human DNA polymerase beta and terminal deoxynucleotidyltransferase. Wilson SH 1987 Gene
Structure of rat DNA polymerase beta revealed by partial amino acid sequencing and cDNA cloning. Wilson SH 1986 Proceedings of the National Academy of Sciences of the United States of America
Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning. Wilson SH 1986 Biochemical and biophysical research communications
Measurement of DNA polymerase beta in skin fibroblast cell lines from patients with ataxia telangiectasia. Wilson SH 1985 Mutation research
Properties and applications of new monoclonal antibodies raised against calf DNA polymerase alpha. Wilson SH 1985 Analytical biochemistry
Synthesis of DNA polymerase by in vitro translation of calf RNA. Wilson SH 1984 Biochem Biophys Res Commun
Heterogeneity in the radiation survival curves and biochemical properties of human lung cancer cell lines. Wilson SH 1984 Journal of the National Cancer Institute
Synthesis of catalytically active polymerase alpha by in vitro translation of calf RNA. Wilson SH 1984 Advances in experimental medicine and biology
Site-specific modification of Escherichia coli DNA polymerase I large fragment with pyridoxal 5'-phosphate. Wilson SH 1984 Biochemistry
Identification of a higher molecular weight DNA polymerase alpha catalytic polypeptide in monkey cells by monoclonal antibody. Wilson SH 1984 Proceedings of the National Academy of Sciences of the United States of America
Improved conditions for activity gel analysis of DNA polymerase catalytic polypeptides. Wilson SH 1983 Anal Biochem
DNA polymerase and simian virus 40 infection of resting monkey cells: induction of aphidicolin resistant alpha-polymerase. Wilson SH 1983 Nucleic acids research
Studies on catalytic subunits of mouse myeloma alpha-polymerase. Wilson SH 1982 The Journal of biological chemistry
Studies on the mechanism of Escherichia coli DNA polymerase I large fragment. Chain termination and modulation by polynucleotides. Wilson SH 1982 The Journal of biological chemistry
Structural homology among calf thymus alpha-polymerase polypeptides. Wilson SH 1982 Nucleic acids research
Studies on the mechanism of DNA polymerase alpha. Nascent chain elongation, steady state kinetics, and the initiation phase of DNA synthesis. Wilson SH 1981 The Journal of biological chemistry
Steady-state kinetics of mouse DNA polymerase beta. Wilson SH 1979 Biochemistry
Mouse DNA polymerase alpha. Subunit structure and identification of a species with associated exonuclease. Wilson SH 1979 The Journal of biological chemistry
Regulation of expression of type C virion DNA polymerase (reverse transcriptase) in human x mouse and human x rat hybrid cells. Wilson SH 1979 Somatic cell genetics
Template specific inhibitor of mammalian DNA polymerases. Wilson SH 1976 Nucleic acids research
Differential response of type C and intracisternal type A particle markers in cells treated with iododeoxyuridine and dexamethasone. Wilson SH 1976 Journal of virology
Studies on DNA alpha-polymerase of mouse myeloma: partial purification and comparison of three molecular forms of the enzyme. Wilson SH 1976 Biochemistry
On the measurement of tritium in DNA and its applications to the assay of DNA polymerase activity. Wilson SH 1976 Methods in cell biology
On the DNA polymerase III of mouse myeloma: partial purification and characterization. Wilson SH 1975 Biochemistry
Differential sensitivity of low molecular weight DNA polymerase to sulfhydryl-blocking reagents. Wilson SH 1975 Biochimica et biophysica acta
Structural studies of avian myeloblastosis virus. Selective release of ribonucleoprotein polypeptides from the core component and partial purification of the DNA polymerase. Wilson SH 1974 Biochimica et biophysica acta
Oncornavirus expression in human x mouse hybrid cells segregating mouse chromosomes. Wilson SH 1974 Proceedings of the National Academy of Sciences of the United States of America
Stimulation of DNA polymerase activity by the combination of p-hydroxymercuribenzoate and dithiothreitol. Wilson SH 1974 Biochemical and biophysical research communications
Studies on the activity of the A particle-associated Dna polymerase. Wilson SH 1974 Cancer research
Multiple forms of DNA polymerase in mouse myeloma. Wilson SH 1974 Proceedings of the National Academy of Sciences of the United States of America
Investigation of methods for measurement of radioactivity in tritiated DNA and applications to assays for DNA polymerase activity. Wilson SH 1973 Analytical biochemistry
Studies on DNA synthesis in murine myeloma. II. Activation of latent RNA-dependent DNA polymerase activity in membrane fractions. Wilson SH 1972 Biochemical and biophysical research communications
A novel DNA polymerase activity found in association with intracisternal A-type particles. Wilson SH 1972 Proceedings of the National Academy of Sciences of the United States of America

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