The X family portrait: structural insights into biological functions of X family polymerases.

Moon AF, Garcia-Diaz M, Batra VK, Beard WA, Bebenek K, Kunkel TA, Wilson SH, Pedersen LC
DNA repair (2007), Volume 6, Page 1709
PubMed entry Publisher's site

Abstract:

The mammalian family X DNA polymerases (DNA polymerases beta, lambda, ...
The mammalian family X DNA polymerases (DNA polymerases beta, lambda, mu, and TdT) contribute to base excision repair and double-strand break repair by virtue of their ability to fill short gaps in DNA. Structural information now exists for all four of these enzymes, making this the first mammalian polymerase family whose structural portrait is complete. Here we consider how distinctive structural features of these enzymes contribute to their biological functions in vivo.

Polymerases:

Human Pol beta,Human Pol lamba,Human Pol mu,Terminal Transferase

Topics:

Mutational Analysis, Historical Protein Properties (MW, pI, ...), Other Enzymatic Activities, Kinetic Parameters, Structure and Structure/Function, Fidelity

Status:

new topics/pols set partial results complete validated

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Version:20241218

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