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Bebenek K

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Publications:

Title Authors Year Journal
Sustained active site rigidity during synthesis by human DNA polymerase μ. Bebenek K 2014 Nature structural & molecular biology
DNA Polymerase λ Inactivation by Oxidized Abasic Sites. Bebenek K 2013 Biochemistry
Altered Ig Hypermutation Pattern and Frequency in Complementary Mouse Models of DNA Polymerase ζ Activity. Bebenek K 2012 Journal of immunology (Baltimore, Md. : 1950)
The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ Bebenek K 2012 Nucleic acids research
Replication infidelity via a mismatch with Watson-Crick geometry. Bebenek K 2011 Proceedings of the National Academy of Sciences of the United States of America
Loop 1 modulates the fidelity of DNA polymerase {lambda} Bebenek K 2010 Nucleic acids research
Inhibition of short patch and long patch base excision repair by an oxidized abasic site. Bebenek K 2010 Biochemistry
Template strand scrunching during DNA gap repair synthesis by human polymerase lambda. Bebenek K 2009 Nature structural & molecular biology
Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ. Bebenek K 2009 PloS one
Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda. Bebenek K 2008 EMBO Rep
Catalytic mechanism of human DNA polymerase lambda with Mg2+ and Mn2+ from ab initio quantum mechanical/molecular mechanical studies. Bebenek K 2008 DNA repair
Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts. Bebenek K 2008 Nucleic acids research
Structural insight into the substrate specificity of DNA Polymerase mu. Bebenek K 2007 Nature structural & molecular biology
Multiple functions of DNA polymerases. Bebenek K 2007 Critical reviews in plant sciences
RNA-templated DNA repair. Bebenek K 2007 Nature
The X family portrait: structural insights into biological functions of X family polymerases. Bebenek K 2007 DNA repair
Role of the catalytic metal during polymerization by DNA polymerase lambda. Bebenek K 2007 DNA repair
Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase. Bebenek K 2006 Cell
Promiscuous mismatch extension by human DNA polymerase lambda. Bebenek K 2006 Nucleic acids research
A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Bebenek K 2005 Molecular cell
Structure-function studies of DNA polymerase lambda. Bebenek K 2005 DNA repair
A closed conformation for the Pol lambda catalytic cycle. Bebenek K 2005 Nature structural & molecular biology
Biochemical properties of Saccharomyces cerevisiae DNA polymerase IV. Bebenek K 2005 The Journal of biological chemistry
A lysine residue in the fingers subdomain of T7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine. Bebenek K 2005 Structure (London, England : 1993)
Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Bebenek K 2004 Cancer research
Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. Bebenek K 2004 The Journal of biological chemistry
A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. Bebenek K 2004 Molecular cell
Functions of DNA polymerases. Bebenek K 2004 Adv Protein Chem
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. Bebenek K 2003 DNA repair
The base substitution fidelity of DNA polymerase beta-dependent single nucleotide base excision repair. Bebenek K 2003 The Journal of biological chemistry
Solution structure of the lyase domain of human DNA polymerase lambda. Bebenek K 2003 Biochemistry
Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. Bebenek K 2003 The Journal of biological chemistry
The frameshift infidelity of human DNA polymerase lambda. Implications for function. Bebenek K 2003 The Journal of biological chemistry
Family growth: the eukaryotic DNA polymerase revolution. Bebenek K 2002 Cell Mol Life Sci
DNA polymerase lambda, a novel DNA repair enzyme in human cells. Bebenek K 2002 The Journal of biological chemistry
Low fidelity DNA synthesis by a y family DNA polymerase due to misalignment in the active site. Bebenek K 2002 The Journal of biological chemistry
Error rate and specificity of human and murine DNA polymerase eta. Bebenek K 2001 Journal of molecular biology
Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. Bebenek K 2001 Nat Immunol
Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair. Bebenek K 2001 The Journal of biological chemistry
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro. Bebenek K 2001 Science
Proofreading of DNA polymerase eta-dependent replication errors. Bebenek K 2001 The Journal of biological chemistry
Vertical-scanning mutagenesis of a critical tryptophan in the "minor groove binding track" of HIV-1 reverse transcriptase. Major groove DNA adducts identify specific protein interactions in the minor groove. Bebenek K 2000 The Journal of biological chemistry
Human DNA polymerase kappa: a novel DNA polymerase of unknown biological function encoded by the DINB1 gene. Bebenek K 2000 Cold Spring Harbor symposia on quantitative biology
Low fidelity DNA synthesis by human DNA polymerase-eta. Bebenek K 2000 Nature
DNA replication fidelity. Bebenek K 2000 Annual review of biochemistry
Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene. Bebenek K 2000 The Journal of biological chemistry
Residues in the alphaH and alphaI helices of the HIV-1 reverse transcriptase thumb subdomain required for the specificity of RNase H-catalyzed removal of the polypurine tract primer. Bebenek K 1999 The Journal of biological chemistry
Uniquely altered DNA replication fidelity conferred by an amino acid change in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase. Bebenek K 1999 The Journal of biological chemistry
The base substitution fidelity of HIV-1 reverse transcriptase on DNA and RNA templates probed with 8-oxo-deoxyguanosine triphosphate. Bebenek K 1999 Mutation research
Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment). Bebenek K 1999 The Journal of biological chemistry
Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions. Bebenek K 1998 The Journal of biological chemistry
A minor groove binding track in reverse transcriptase. Bebenek K 1997 Nat Struct Biol
Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-guanine adducts. Bebenek K 1997 The Journal of biological chemistry
Exonucleolytic proofreading during replication of repetitive DNA. Bebenek K 1996 Biochemistry
Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain. Bebenek K 1995 The Journal of biological chemistry
Analyzing fidelity of DNA polymerases. Bebenek K 1995 Methods in enzymology
Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase. Alanine scanning mutagenesis of an alpha-helix in the thumb subdomain. Bebenek K 1994 The Journal of biological chemistry
Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots. Bebenek K 1993 The Journal of biological chemistry
Mechanism of HIV-1 reverse transcriptase. Termination of processive synthesis on a natural DNA template is influenced by the sequence of the template-primer stem. Bebenek K 1993 The Journal of biological chemistry
Structure/function studies of HIV-1(1) reverse transcriptase: dimerization-defective mutant L289K. Bebenek K 1993 Biochemistry
The effects of dNTP pool imbalances on frameshift fidelity during DNA replication. Bebenek K 1992 The Journal of biological chemistry
Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine. Bebenek K 1992 The Journal of biological chemistry
Unequal human immunodeficiency virus type 1 reverse transcriptase error rates with RNA and DNA templates. Bebenek K 1992 Proceedings of the National Academy of Sciences of the United States of America
Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae. Identification of the catalytic core and a possible holoenzyme form of the enzyme. Bebenek K 1990 The Journal of biological chemistry
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I. Bebenek K 1990 The Journal of biological chemistry
Frameshift errors initiated by nucleotide misincorporation. Bebenek K 1990 Proceedings of the National Academy of Sciences of the United States of America
The use of native T7 DNA polymerase for site-directed mutagenesis. Bebenek K 1989 Nucleic acids research
Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase. Bebenek K 1989 The Journal of biological chemistry
The accuracy of reverse transcriptase from HIV-1. Bebenek K 1988 Science (New York, N.Y.)

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