Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ.

Terrados G, Capp JP, Canitrot Y, García-Díaz M, Bebenek K, Kirchhoff T, Villanueva A, Boudsocq F, Bergoglio V, Cazaux C, Kunkel TA, Hoffmann JS, Blanco L
PloS one (2009), Volume 4, Page e7290
PubMed entry Full article text Publisher's site

Abstract:

DNA polymerase lambda (Pollambda) is a DNA repair polymerase, which ...
DNA polymerase lambda (Pollambda) is a DNA repair polymerase, which likely plays a role in base excision repair (BER) and in non-homologous end joining (NHEJ) of DNA double-strand breaks (DSB).

Polymerases:

Human Pol lamba

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