Human Pol lamba
From
H. sapiens
(genes: POLL )
Welcome to the Polymerase Page
This page presents all the information in Polbase for Human Pol lamba.
Mutants:At the top of the page you'll find a map of all positions of known mutants. Text links to mutants and digestion products are listed in the Mutants section.
Structures/Sequence:If available, a representative structure is displayed at the upper right. All known structures are listed in the Structures section.
External links:Polbase polymerases are linked to UniProt and Genbank where possible. The UniProt search link directs you to a pre-constructed UniProt search containing relevant terms.
References:All references that refer to this Polymerase are listed with their topics and paper's title in the References table.
Results:All the results for this polymerase can be examined by following the "Results" link at the bottom of the page.
Help icons:
The symbol in the upper-right corner of the page
links to this help text. The question mark icon is used everywhere to indicate that help is available.
Human Pol lamba
is a family X enzyme
from
H. sapiens.
Selected Properties for Human Pol lamba: |
3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| No (3) | No (1) | 4.9e-03 errors/bp (1) | 9.0e-04-9.0e-04 errors/bp (2) | no data |
- References (59)
- Structures (28)
- Sequences (1)
- Mutants (1)...
- Formulations (0)
- Polymerase Lots (0)
- External links
| Year | Authors | Title | Results by property |
|---|---|---|---|
| 2013 | Adam J Stevens, Lirui Guan, Katarzyna Bebenek, Thomas A Kunkel, Marc M Greenberg | DNA Polymerase λ Inactivation by Oxid... | |
| 2013 | Tobias Strittmatter, Anette Brockmann, Moritz Pott, Annika Hantusch, Thomas Brunner, Andreas Marx | Expanding the Scope of Human DNA Poly... | |
| 2012 | Lidia V Skosareva, Natalia A Lebedeva, Nadejda I Rechkunova, Alexander Kolbanovskiy, Nicholas E Geacintov, Olga I Lavrik | Human DNA polymerase λ catalyzes lesi... | |
| 2012 | Rajendrakumar A Gosavi, Andrea F Moon, Thomas A Kunkel, Lars C Pedersen, Katarzyna Bebenek | The catalytic cycle for ribonucleotid... | |
| 2011 | Katarzyna Bebenek, Lars C Pedersen, Thomas A Kunkel | Replication infidelity via a mismatch... | |
| 2011 | Kazuki Kobayashi, Shin Nishiumi, Masayuki Nishida, Midori Hirai, Takeshi Azuma, Hiromi Yoshida, Yoshiyuki Mizushina, Masaru Yoshida | Effects of quinone derivatives, such ... | |
| 2011 | Tobias Strittmatter, Bettina Bareth, Timo A Immel, Thomas Huhn, Thomas U Mayer, Andreas Marx | Small Molecule Inhibitors of Human DN... | |
| 2011 | Enni Markkanen, Barbara van Loon, Elena Ferrari, Jason L Parsons, Grigory L Dianov, Ulrich Hübscher | Regulation of oxidative DNA damage re... | |
| 2011 | Emmanuele Crespan, Giovanni Maga, Ulrich Hübscher | A new proofreading mechanism for lesi... | |
| 2010 | Jennifer Yamtich, Joann B Sweasy | DNA polymerase family X: function, st... | Full length or truncated,Gap fill,Terminal Transferase,3-5' exo,5-3' exo,Molecular Weight,Vmax,Other accessory protein(s),Template lesions,All properties |
| 2010 | Jessica A Brown, Lindsey R Pack, Shanen M Sherrer, Ajay K Kshetry, Sean A Newmister, Jason D Fowler, John-Stephen Taylor, Zucai Suo | Identification of critical residues f... | |
| 2010 | Miguel Garcia-Diaz, Michael S Murray, Thomas A Kunkel, Kai-Ming Chou | The interaction between DNA polymeras... | |
| 2010 | Lirui Guan, Katarzyna Bebenek, Thomas A Kunkel, Marc M Greenberg | Inhibition of short patch and long pa... | |
| 2010 | Katarzyna Bebenek, Miguel Garcia-Diaz, Rui-Zhe Zhou, Lawrence F Povirk, Thomas A Kunkel | Loop 1 modulates the fidelity of DNA ... | KM,kcat,All properties |
| 2010 | Mark D Sutton | Coordinating DNA polymerase traffic d... | |
| 2010 | Jean-Pascal Capp, François Boudsocq, Valérie Bergoglio, Didier Trouche, Christophe Cazaux, Luis Blanco, Jean-Sébastien Hoffmann, Yvan Canitrot | The R438W polymorphism of human DNA p... | |
| 2009 | Jason D Fowler, Jessica A Brown, Mamuka Kvaratskhelia, Zucai Suo | Probing conformational changes of hum... | |
| 2009 | Gloria Terrados, Jean-Pascal Capp, Yvan Canitrot, Miguel García-Díaz, Katarzyna Bebenek, Tomas Kirchhoff, Alberto Villanueva, François Boudsocq, Valérie Bergoglio, Christophe Cazaux, Thomas A Kunkel, Jean-Sébastien Hoffmann, Luis Blanco | Characterization of a natural mutator... | |
| 2009 | Barbara van Loon, Ulrich Hübscher | An 8-oxo-guanine repair pathway coord... | |
| 2008 | Giovanni Maga, Emmanuele Crespan, Ursula Wimmer, Barbara van Loon, Alessandra Amoroso, Chiara Mondello, Cristina Belgiovine, Elena Ferrari, Giada A Locatelli, Giuseppe Villani, Ulrich Hübscher | Replication protein A and proliferati... | |
| 2008 | Masayuki Nishida, Noriko Ida, Mao Horio, Toshifumi Takeuchi, Shinji Kamisuki, Hiroshi Murata, Kouji Kuramochi, Fumio Sugawara, Hiromi Yoshida, Yoshiyuki Mizushina | Hymenoic acid, a novel specific inhib... | |
| 2008 | Vinod K Batra, William A Beard, David D Shock, Lars C Pedersen, Samuel H Wilson | Structures of DNA polymerase beta wit... | |
| 2008 | Katarzyna Bebenek, Miguel Garcia-Diaz, Meredith C Foley, Lars C Pedersen, Tamar Schlick, Thomas A Kunkel | Substrate-induced DNA strand misalign... | |
| 2008 | Patrick P Lestienne, François Boudsocq, Jacques E Bonnet | Initiation of DNA replication by a th... | |
| 2008 | G Andrés Cisneros, Lalith Perera, Miguel García-Díaz, Katarzyna Bebenek, Thomas A Kunkel, Lee G Pedersen | Catalytic mechanism of human DNA poly... | |
| 2007 | Angel J Picher, Luis Blanco | Human DNA polymerase lambda is a prof... | |
| 2007 | Andrea F Moon, Miguel Garcia-Diaz, Vinod K Batra, William A Beard, Katarzyna Bebenek, Thomas A Kunkel, Samuel H Wilson, Lars C Pedersen | The X family portrait: structural ins... | |
| 2007 | Robert S Pitcher, Nigel C Brissett, Angel J Picher, Paula Andrade, Raquel Juarez, Darren Thompson, Gavin C Fox, Luis Blanco, Aidan J Doherty | Structure and function of a mycobacte... | Terminal Transferase,All properties |
| 2007 | Fu Gu, Chun You, JianPing Liu, Ao Chen, Yao Yu, Xiang Wang, DaFang Wan, JianRen Gu, HanYing Yuan, Yingqian Li, Hong Lü | Cloning, expression and characterizat... | |
| 2007 | Shinji Kamisuki, Chisato Ishimaru, Kadohiro Onoda, Isoko Kuriyama, Noriko Ida, Fumio Sugawara, Hiromi Yoshida, Yoshiyuki Mizushina | Nodulisporol and Nodulisporone, novel... | |
| 2007 | Jessica A Brown, Wade W Duym, Jason D Fowler, Zucai Suo | Single-turnover kinetic analysis of t... | |
| 2007 | Miguel Garcia-Diaz, Katarzyna Bebenek, Joseph M Krahn, Lars C Pedersen, Thomas A Kunkel | Role of the catalytic metal during po... | |
| 2007 | Emmanuele Crespan, Ulrich Hübscher, Giovanni Maga | Error-free bypass of 2-hydroxyadenine... | |
| 2006 | Kevin A Fiala, Wade W Duym, Jun Zhang, Zucai Suo | Up-regulation of the fidelity of huma... | |
| 2006 | Miguel Garcia-Diaz, Katarzyna Bebenek, Joseph M Krahn, Lars C Pedersen, Thomas A Kunkel | Structural analysis of strand misalig... | |
| 2006 | Toshifumi Takeuchi, Tomomi Ishidoh, Hiroshi Iijima, Isoko Kuriyama, Noriko Shimazaki, Osamu Koiwai, Kouji Kuramochi, Susumu Kobayashi, Fumio Sugawara, Kengo Sakaguchi, Hiromi Yoshida, Yoshiyuki Mizushina | Structural relationship of curcumin d... | |
| 2006 | Wade W Duym, Kevin A Fiala, Nikunj Bhatt, Zucai Suo | Kinetic effect of a downstream strand... | |
| 2006 | Giovanni Maga, Igor V Shevelev, Giuseppe Villani, Silvio Spadari, Ulrich Hübscher | Human replication protein A can suppr... | |
| 2006 | Angel J Picher, Miguel García-Díaz, Katarzyna Bebenek, Lars C Pedersen, Thomas A Kunkel, Luis Blanco | Promiscuous mismatch extension by hum... | |
| 2005 | Miguel Garcia-Diaz, Katarzyna Bebenek, Joseph M Krahn, Thomas A Kunkel, Lars C Pedersen | A closed conformation for the Pol lam... | |
| 2005 | Giovanni Maga, Kristijan Ramadan, Giada A Locatelli, Igor V Shevelev, Silvio Spadari, Ulrich Hübscher | DNA elongation by the human DNA polym... | |
| 2005 | Isabelle Frouin, Magali Toueille, Elena Ferrari, Igor V Shevelev, Ulrich Hübscher | Phosphorylation of human DNA polymera... | |
| 2005 | Emmanuele Crespan, Samantha Zanoli, Anastasiya Khandazhinskaya, Igor V Shevelev, Maxim Jasko, Ludmila Alexandrova, Marina Kukhanova, Giuseppina Blanca, Giuseppe Villani, Ulrich Hübscher, Silvio Spadari, Giovanni Maga | Incorporation of non-nucleoside triph... | |
| 2004 | Miguel Garcia-Diaz, Katarzyna Bebenek, Joseph M Krahn, Luis Blanco, Thomas A Kunkel, Lars C Pedersen | A structural solution for the DNA pol... | |
| 2004 | Kevin A Fiala, Wissam Abdel-Gawad, Zucai Suo | Pre-steady-state kinetic studies of t... | |
| 2004 | Kristijan Ramadan, Igor V Shevelev, Giovanni Maga, Ulrich Hübscher | De novo DNA synthesis by human DNA po... | |
| 2004 | Giuseppina Blanca, Giuseppe Villani, Igor V Shevelev, Kristijan Ramadan, Silvio Spadari, Ulrich Hübscher, Giovanni Maga | Human DNA polymerases lambda and beta... | |
| 2004 | Giovanni Maga, Giuseppina Blanca, Igor V Shevelev, Isabelle Frouin, Kristijan Ramadan, Silvio Spadari, Giuseppe Villani, Ulrich Hübscher | The human DNA polymerase lambda inter... | |
| 2003 | Giuseppina Blanca, Igor V Shevelev, Kristijan Ramadan, Giuseppe Villani, Silvio Spadari, Ulrich Hübscher, Giovanni Maga | Human DNA polymerase lambda diverged ... | |
| 2003 | Igor V Shevelev, Giuseppina Blanca, Giuseppe Villani, Kristijan Ramadan, Silvio Spadari, Ulrich Hübscher, Giovanni Maga | Mutagenesis of human DNA polymerase l... | |
| 2003 | Kristijan Ramadan, Giovanni Maga, Igor V Shevelev, Giuseppe Villani, Luis Blanco, Ulrich Hübscher | Human DNA polymerase lambda possesses... | |
| 2003 | Eugene F DeRose, Thomas W Kirby, Geoffrey A Mueller, Katarzyna Bebenek, Miguel Garcia-Diaz, Luis Blanco, Thomas A Kunkel, Robert E London | Solution structure of the lyase domai... | |
| 2003 | Katarzyna Bebenek, Miguel Garcia-Diaz, Luis Blanco, Thomas A Kunkel | The frameshift infidelity of human DN... | Full length or truncated,Gap fill,Terminal Transferase,3-5' exo,Frameshift Error Rate,Nucleotide Substitution Rate,All properties |
| 2002 | Noriko Shimazaki, Kenta Yoshida, Toshiko Kobayashi, Shingo Toji, Katsuyuki Tamai, Osamu Koiwai | Over-expression of human DNA polymera... | Cloned or native,Tagged,Tag Name,Full length or truncated,Specific Activity,Processivity,Molecular Weight,All properties |
| 2002 | Ulrich Hubscher, Giovanni Maga, Silvio Spadari | Eukaryotic DNA polymerases. | |
| 2002 | Yoshiyuki Mizushina, Shinji Kamisuki, Nobuyuki Kasai, Tomomi Ishidoh, Noriko Shimazaki, Masaharu Takemura, Hitomi Asahara, Stuart Linn, Shonen Yoshida, Osamu Koiwai, Fumio Sugawara, Hiromi Yoshida, Kengo Sakaguchi | Petasiphenol: a DNA polymerase lambda... | |
| 2002 | Miguel García-Díaz, Katarzyna Bebenek, Rosario Sabariegos, Orlando Domínguez, Josana Rodríguez, Tomas Kirchhoff, Esther García-Palomero, Angel J Picher, Raquel Juárez, José F Ruiz, Thomas A Kunkel, Luis Blanco | DNA polymerase lambda, a novel DNA re... | Cloned or native,Full length or truncated,Processivity,3-5' exo,Nucleotide Substitution Rate,KM,Molecular Weight,All properties |
| 2002 | Giovanni Maga, Giuseppe Villani, Kristijan Ramadan, Igor V Shevelev, Nicolas Tanguy Le Gac, Luis Blanco, Giuseppina Blanca, Silvio Spadari, Ulrich Hübscher | Human DNA polymerase lambda functiona... | |
| 2001 | Miguel García-Díaz, Katarzyna Bebenek, Thomas A Kunkel, Luis Blanco | Identification of an intrinsic 5'-deo... |
Protein sequence:
| Name | 3'-5' exo activity | 5'-3' exo activity | Frameshift Rate | Substitution Rate | General Error Rate |
|---|---|---|---|---|---|
| Pol lamba L277A/H511A/R514 |
Protein information: Uniprot Q9UGP5 search for Human Pol lamba at UniProt
Sequence information: NCBI nucleotides European nucleotide archive